Fig. 1 · Structure
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1,1-Dimethylethyl 4-(3-azetidinylmethyl)-1-piperazinecarboxylate
PROTAC Linker
1,1-Dimethylethyl 4-(3-azetidinylmethyl)-1-piperazinecarboxylate serves as a PROTAC (Proteolysis Targeting Chimera) linker, facilitating the synthesis of bifunctional molecules that induce targeted degradation of specific proteins via the ubiquitin-proteasome pathway. This compound exhibits key biological activity in the design of therapeutic agents aimed at modulating protein levels, thus playing a significant role in pharmaceutical research focusing on targeted protein degradation. Its applications extend to the development of innovative strategies for treating various diseases through selective protein downregulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1780637-40-2 |
| Applications | PROTAC Linker |
| Formula | C13H25N3O2 |
| Molecular Weight | 255.36 |
| SMILES | O=C(OC(C)(C)C)N1CCN(CC1)CC2CNC2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.