Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC linker
NH2-C2-NH-Boc (PROTAC Linker 22) is a PROTAC linker, which refers to the alkyl chain composition.NH2-C2-NH-Boc can be used in the synthesis of a series of PROTACs. -
PROTAC linker
Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is a PROTAC linker can be used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs). -
PROTAC linker
VH032-PEG5-C6-Cl (HaloPROTAC 2) is a small molecule HaloPROTAC that incorporates the VH032 based VHL ligand and 5-unit PEG linker. -
PROTAC linker
Pomalidomide-PEG4-C-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. -
PROTAC linker
Dox-Ph-PEG1-Cl (PROTAC Linker 34) is a PROTAC linker, which refers to the PEG composition. Dox-Ph-PEG1-Cl can be used in the synthesis of a series of PROTACs. -
PROTAC linker
Boc-NH-C6-amido-C4-acid is a PROTAC linker, which refers to the alkyl/ether composition. Boc-NH-C6-amido-C4-acid can be used in the synthesis of a series of PROTACs. -
PEG PROTAC linker
PEG6-(CH2CO2H)2 is a PEG derivative containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. -
PROTAC linker
Boc-NH-PEG2-C2-amido-C4-acid (PROTAC Linker 30) is a PROTAC linker, which refers to the PEG composition. Boc-NH-PEG2-C2-amido-C4-acid can be used in the synthesis of a series of PROTACs. -
PROTAC linker
NH2-Ph-C4-acid-NH2-Me (PROTAC Linker 31) is a PROTAC linker, which refers to the Alkyl-Chain composition. NH2-Ph-C4-acid-NH2-Me can be used in the synthesis of a series of PROTACs. -
PROTAC linker
Bis-PEG1-C-PEG1-CH2COOH (PROTAC Linker 26) is a PROTAC linker, which refers to the PEG composition. Bis-PEG1-C-PEG1-CH2COOH can be used in the synthesis of a series of PROTACs. -
PROTAC linker
Bis-NH2-C1-PEG3 (PROTAC Linker 24) is a PROTAC linker, which refers to the alkyl/ether composition. Bis-NH2-C1-PEG3 can be used in the synthesis of a series of PROTACs. -
PROTAC linker
Phenol-amido-C1-PEG3-N3 (PROTAC Linker 21) is a PROTAC linker, which refers to the PEG composition. Phenol-amido-C1-PEG3-N3 can be used in the synthesis of a series of PROTACs. -
PROTAC linker
N3-PEG4-C2-NH2 (PROTAC Linker 20) is a polyethylene glycol (PEG)-based PROTAC linker. N3-PEG4-C2-NH2 can be used in the synthesis of a series of PROTACs. -
PROTAC linker
Bis-NH2-PEG2 (PROTAC Linker 19) is a PROTAC linker, which refers to the PEG composition. Bis-NH2-PEG2 can be used in the synthesis of a series of PROTACs. -
PROTAC linker
cIAP1 Ligand-Linker Conjugates 1 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 1 can be used to design SNIPERs. -
PROTAC linker
cIAP1 Ligand-Linker Conjugates 3 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 3 can be used to design SNIPERs. -
PROTAC linker
cIAP1 Ligand-Linker Conjugates 5 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 5 can be used to design SNIPERs. -
PROTAC linker
cIAP1 Ligand-Linker Conjugates 12 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 12 can be used to design SNIPERs. -
PROTAC linker
cIAP1 Ligand-Linker Conjugates 2 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 2 can be used to design SNIPERs. -
PROTAC linker
cIAP1 Ligand-Linker Conjugates 14 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 14 can be used to design SNIPERs. -
PROTAC linker
cIAP1 Ligand-Linker Conjugates 15 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 15 can be used to design SNIPERs. -
PROTAC linker
cIAP1 Ligand-Linker Conjugates 11 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 11 can be used to design SNIPERs. -
PROTAC linker
Tos-PEG3-NH-Boc (PROTAC Linker 9) is a PROTAC linker, which refers to the PEG composition. Tos-PEG3-NH-Boc can be used in the synthesis of a series of PROTACs. -
PROTAC linker
PEG3-O-CH2COOH (Compound 15b) is a PROTAC linker can be used in the synthesis of a series of SNIPER(ER)s. -
PROTAC linker
Tos-PEG4-NH-Boc (PROTAC Linker 7) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-NH-Boc can be used in the synthesis of a series of PROTACs. -
PROTAC linker
Tos-PEG3-O-C1-CH3COO (PROTAC Linker 6) is a PROTAC linker, which refers to the PEGs composition. -
PROTAC linker
NH2-PEG3-C1-Boc (PROTAC Linker 5) is a PROTAC linker, which refers to the PEG composition. NH2-PEG3-C1-Boc can be used in the synthesis of a series of PROTACs. -
PROTAC linker
Boc-C5-O-C5-O-C6-Cl (PROTAC Linker 2) is a PROTAC linker utilized to connect the respective tyrosine kinase inhibitor (TKI) to the E3 recruiting ligand. - Boc-C1-PEG2-C4-Cl (PROTAC Linker 1) is a PROTAC linker utilized to connect the respective tyrosine kinase inhibitor (TKI) to the E3 recruiting ligand.
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PROTAC linker
N33-TEG-COOH is a PROTAC linker containing four polyethylene glycol (PEG) units. -
PROTAC linker
NH2-PEG3-C2-NH-Boc is a PROTAC linker, which refers to the PEG composition. -
PROTAC linker
N3-PEG3-CH2COOH (PROTAC Linker 14) is a PROTAC linker, which refers to the PEG composition. -
PROTAC Linker
MAK683-CH2CH2COOH is a PROTAC linker that specifically binds to embryonic ectoderm development protein (EED). This compound is instrumental in facilitating targeted protein degradation when paired with a VHL ligand for E3 ubiquitin ligase. Research applications include the development of PROTAC EED degrader-1 and PROTAC EED degrader-2, making it a valuable tool for studying EED-related pathways and therapeutic interventions. -
PROTAC Linkers
Biotin-PEG6-Thalidomide serves as a PEG-based PROTAC linker, instrumental in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound enhances the delivery and cellular penetration of targeted proteins for ubiquitination and subsequent degradation. Its unique design facilitates the exploration of protein modulation in various biological contexts and therapeutic applications, making it an essential tool for researchers investigating targeted protein degradation processes. -
PROTAC Linkers
Thalidomide-O-amido-PEG4-propargyl is a PEG-based PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an alkyne functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) for efficient conjugation with azide-containing molecules. Its unique properties enable precise modulation of target protein degradation, supporting research in targeted protein modulation and therapeutic applications. -
PROTAC Linkers
Thalidomide-O-amido-PEG4-azide is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound possesses an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. This makes Thalidomide-O-amido-PEG4-azide a versatile tool in targeted protein degradation applications and chemical biology research. -
PROTAC Linker
Thalidomide-NH-C5-NH2 serves as a PROTAC linker, facilitating the recruitment of E3 ligases through its thalidomide-based cereblon ligand. This compound enables targeted protein degradation, making it a valuable tool in drug discovery and development. Its application in the design of bifunctional degraders enhances the specificity and efficacy of therapeutic strategies aimed at modulating protein functions in various biological contexts. -
TLR4 Inhibitor/PROTAC Linker
TLR4-IN-C34-C2-COOH is a TLR4 inhibitor that serves as a PROTAC linker. It demonstrates significant potential in the modulation of inflammatory responses, particularly in studies involving acute myocardial injury. By targeting TLR4 in enterocytes and macrophages, TLR4-IN-C34-C2-COOH effectively reduces systemic inflammation in murine models of endotoxemia and necrotizing enterocolitis, making it a valuable tool for research in inflammation-related pathways. -
ADC/PROTAC Linkers
Glucocorticoid receptor agonist-1 phosphate(2,6-difluoro) Ala-Ala-Br serves as a versatile drug-linker conjugate for antibody-drug conjugate (ADC) applications. This reagent enables the synthesis of conjugates targeting the CD40 antigen, facilitating the development of targeted therapies. Its unique structure supports the design of PROTACs and other innovative bio-conjugates, contributing to advances in cancer research and immunotherapy. -
PROTAC Linker
N-(Azido-PEG3)-N-Fluorescein-PEG3-acid is a PEG-based linker utilized in PROTAC technology, featuring azide, fluorescein, and carboxylic acid functionalities. This compound serves as a versatile click chemistry reagent capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Its unique properties make it suitable for applications in tandem with targeted protein degradation and fluorescent labeling studies in chemical biology. -
PROTAC Linker
Biotin-PEG-azide (MW 1000) is a PEG-based linker designed for PROTAC synthesis, featuring an azide functional group. This versatile compound can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules, as well as in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized compounds. Its unique properties make it suitable for applications in targeted protein degradation research and other areas of chemical biology. -
PROTAC Linkers
DBCO-NHCO-PEG12-biotin is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through its reactive DBCO moiety. This compound engages in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules, allowing for precise conjugation in chemical biology applications. Its utility in targeted protein degradation research makes it a valuable tool for biochemists developing innovative therapeutic strategies. -
PROTAC Linkers
Carboxyfluorescein-PEG12-NHS is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). It enables the formation of covalent bonds with target proteins, facilitating the selective degradation of unwanted intracellular proteins. This reagent is valuable for researchers exploring targeted protein degradation and developing novel therapeutics in cancer and other diseases. -
PROTAC Linker
(Rac)-Biotin-PEG3-oxyamine hydrochloride is a PEG-based linker specifically designed for the development of PROTAC (Proteolysis Targeting Chimera) molecules. This compound facilitates the conjugation of biotin to target proteins, enhancing their degradation via the ubiquitin-proteasome pathway. It is valuable in research applications focused on targeted protein degradation and the study of protein-protein interactions. -
PROTAC Linkers
Fmoc-NH-PEG5-CH2COOH is a cleavable linker specifically designed for use in antibody-drug conjugates (ADCs) and as a PEG-based link in the synthesis of PROTACs. This compound facilitates the efficient conjugation of therapeutic agents to antibodies, enhancing targeted delivery. Its unique structure allows for controlled release, making it valuable in the development of innovative therapeutic strategies in drug discovery and bioconjugation research. -
ADC/PROTAC Linker
DBCO-NHCO-PEG4-NH-Boc is a versatile PROTAC linker featuring a cleavable structure designed for the synthesis of PROTACs and antibody-drug conjugates (ADCs). This compound utilizes a DBCO moiety, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its PEG4 spacer enhances solubility and stability, making it suitable for various biological applications in drug development and therapeutic research. -
ADC/PROTAC Linker
DBCO-NHCO-PEG4-amine is a PEG-based linker designed for use in antibody-drug conjugates (ADCs) and PROTACs. This cleavable linker facilitates the conjugation of payloads such as MMAE to antibodies, enhancing targeted delivery to cancer cells. It has demonstrated compelling biological activities, with EC50 values of 280 nM and 22 nM for DBCO-VCpAB MMAE and DBCO-TRX MMAE, respectively, in SKBR3 cells, making it a valuable tool for researchers investigating targeted therapies. -
ADC/PROTAC Linker
Tr-PEG3-OH is a non-cleavable linker comprised of a three-unit polyethylene glycol (PEG) chain, designed for use in the synthesis of antibody-drug conjugates (ADCs). This compound enhances the solubility and stability of ADCs, facilitating targeted delivery of cytotoxic agents to specific cells. Its applications extend to PROTAC (proteolysis-targeting chimera) technology, enabling the development of innovative therapies that harness targeted protein degradation. -
ADC/PROTAC Linker
Propargyl-PEG7-acid is a PEG-based linker designed for use in antibody-drug conjugates (ADCs) and proteolysis-targeting chimeras (PROTACs). It features a propargylic group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling effective conjugation to azide-containing molecules. This compound serves as a cleavable linker, providing versatility in drug delivery systems and targeted therapy research. Propargyl-PEG7-acid is essential for studies focusing on the development of innovative therapeutic modalities through advanced chemical synthesis techniques.
