1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA is a phospholipid that features arachidonic acid at the sn-1 position and serves as a precursor to 1-arachidonoyl glycerol. This compound exhibits potent binding to the LPA2/EDG4 receptor, with an EC50 value of approximately 10 nM. Its biological activity includes the inhibition of TNF-α and IL-6 secretion in wild-type dendritic cells activated by LPS, as well as the reduction of HT-29 human colon carcinoma cell differentiation into goblet cells upon sodium butyrate treatment. This makes it a valuable tool for studying inflammation and cancer biology.
1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA is a phospholipid that features arachidonic acid at the sn-1 position and serves as a precursor to 1-arachidonoyl glycerol. This compound exhibits potent binding to the LPA2/EDG4 receptor, with an EC50 value of approximately 10 nM. Its biological activity includes the inhibition of TNF-α and IL-6 secretion in wild-type dendritic cells activated by LPS, as well as the reduction of HT-29 human colon carcinoma cell differentiation into goblet cells upon sodium butyrate treatment. This makes it a valuable tool for studying inflammation and cancer biology.
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