11-Ketodihydrotestosterone (11-KDHT) is a potent androgen receptor (AR) agonist, exhibiting a Ki of 20.4 nM and an EC50 of 1.35 nM for human AR. This endogenous steroid, a metabolite of 11β-Hydroxyandrostenedione, plays a significant role in regulating gene expression, protein synthesis, and cellular growth, particularly in androgen-dependent prostate cancer cells. Its ability to activate AR makes it valuable for research into androgen signaling pathways and the development of therapeutic strategies for prostate cancer.
11-Ketodihydrotestosterone (11-KDHT) is a potent androgen receptor (AR) agonist, exhibiting a Ki of 20.4 nM and an EC50 of 1.35 nM for human AR. This endogenous steroid, a metabolite of 11β-Hydroxyandrostenedione, plays a significant role in regulating gene expression, protein synthesis, and cellular growth, particularly in androgen-dependent prostate cancer cells. Its ability to activate AR makes it valuable for research into androgen signaling pathways and the development of therapeutic strategies for prostate cancer.
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