14-(Fmoc-amino)-tetradecanoic acid serves as a versatile PROTAC linker in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups, enabling efficient conjugation strategies. The Fmoc group can be removed under basic conditions to yield a free amine suitable for subsequent reactions. The terminal carboxylic acid can react with primary amines in the presence of coupling agents, such as EDC or HATU, facilitating the formation of stable amide bonds crucial for PROTAC development.
14-(Fmoc-amino)-tetradecanoic acid serves as a versatile PROTAC linker in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups, enabling efficient conjugation strategies. The Fmoc group can be removed under basic conditions to yield a free amine suitable for subsequent reactions. The terminal carboxylic acid can react with primary amines in the presence of coupling agents, such as EDC or HATU, facilitating the formation of stable amide bonds crucial for PROTAC development.
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