(1S,3R)-GNE-502 is a selective estrogen receptor alpha (ERα) degrader, exhibiting a potent EC50 of 13 nM in MCF7 human breast cancer cells. This compound effectively downregulates ERα levels, making it a valuable tool for investigating estrogen-mediated signaling pathways in cancer research. Its application extends to exploring therapeutic strategies for ERα-positive breast cancer and understanding the biological mechanisms underlying estrogen receptor regulation.
(1S,3R)-GNE-502 is a selective estrogen receptor alpha (ERα) degrader, exhibiting a potent EC50 of 13 nM in MCF7 human breast cancer cells. This compound effectively downregulates ERα levels, making it a valuable tool for investigating estrogen-mediated signaling pathways in cancer research. Its application extends to exploring therapeutic strategies for ERα-positive breast cancer and understanding the biological mechanisms underlying estrogen receptor regulation.
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