2,5-Dioxopyrrolidin-1-yl 2-(2-(prop-2-yn-1-yloxy)ethoxy)acetate

Catalog No.: A84083
PROTAC Linker
2,5-Dioxopyrrolidin-1-yl 2-(2-(prop-2-yn-1-yloxy)ethoxy)acetate serves as a highly functional PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound enhances the targeted degradation of specific proteins through ubiquitin-proteasome pathways. It is essential for researchers focused on developing selective protein degraders in therapeutic applications, particularly in cancer and other diseases driven by aberrant protein levels.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description2,5-Dioxopyrrolidin-1-yl 2-(2-(prop-2-yn-1-yloxy)ethoxy)acetate serves as a highly functional PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound enhances the targeted degradation of specific proteins through ubiquitin-proteasome pathways. It is essential for researchers focused on developing selective protein degraders in therapeutic applications, particularly in cancer and other diseases driven by aberrant protein levels.
Product Information
Catalog NumA84083
FormulaC11H13NO6
Molecular Weight255.23
CAS Number2244145-13-7
SMILESO=C(ON1C(=O)CCC1=O)COCCOCC#C
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