Fig. 1 · Structure
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2’-Azido-2’-deoxycytidine
Purine Nucleoside Analog
2’-Azido-2’-deoxycytidine is a purine nucleoside analogue that exhibits significant anticancer properties by inhibiting DNA synthesis and inducing apoptosis, particularly in indolent lymphoid malignancies. This compound serves as a versatile click chemistry reagent, containing an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne, DBCO, or BCN-containing molecules. Additionally, 2’-Azido-2’-deoxycytidine requires dual phosphorylation to function as an inhibitor of ribonucleotide reductase, positioning it as a valuable tool in cancer research and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 51034-68-5 |
| Applications | Purine Nucleoside Analog |
| Formula | C9H12N6O4 |
| Molecular Weight | 268.23 |
| SMILES | OC[C@@H]1[C@@H](O)[C@@H](N=[N+]=[N-])[C@H](N2C(N=C(N)C=C2)=O)O1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.