Nucleoside Antimetabolite/Analog

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  1. PNP inhibitor

    CI 972 is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent.
  2. 1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine is a bicyclic nucleoside.
  3. 2'-Deoxypseudoisocytidine is a nucleoside analogue.
  4. DMTr-LNA-5MeU-3-CED-phosphoramidite is a nucleoside derivative.
  5. PNP inhibitor

    Forodesine(BCX-1777 freebase; Immucillin-H) is an orally bioavailable PNP inhibitor with picomolar potency; induces apoptosis, mainly in T cells.
  6. PNP inhibitor

    Forodesine hydrochloride (BCX-1777) is a highly potent and specific purine nucleoside phosphorylase (PNP) inhibitor.
  7. Tenofovir exalidex, also known as HDP-Tenofovir and CMX-157, is a novel lipid acyclic nucleoside phosphonate that delivers high intracellular concentrations of the active antiviral agent tenofovir.
  8. Riamilovir, also known as Triazavirin, is a nucleoside analogue of nucleic acid and an antiviral agent, works by inhibiting the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is shown active in inhibition of the tick-borne encephalitis virus reproduction (strain Sofiin) by accumulation in the SKEV cell culture.

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