Nucleoside Antimetabolite/Analog

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  1. Fosteabine is an oral and prodrug analogue of cytarabine which is resistant to deoxycytidine deaminase.
  2. modified nucleoside

    6-O-Methyl Guanosine is a modified nucleoside. 6-O-Methyl Guanosine (6-methylguanosine) inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line.
  3. N2-methylguanosine is a modified nucleoside that occurs at several specific locations in many tRNA's.
  4. biomarker

    N6-Etheno 2'-deoxyadenosine is a reactive oxygen species (ROS)/reactive nitrogen species (RNS)-induced DNA oxidation product, used as a biomarker to evaluate chronic inflammation and lipid peroxidation in animal or human tissues.
  5. 3-Methylcytidine, a urinary nucleoside, can be used as a biomarker of four different types of cancer: lung cancer, gastric cancer, colon cancer, and breast cancer.
  6. 3'-Azido-3'-deoxy-beta-L-uridine (Compound 25) is a nucleoside derivative.
  7. N6,N6-Dimethyladenosine is a modified ribonucleoside previously found in rRNA, and also exhibits in mycobacterium bovis Bacille Calmette-Gu??rin tRNA.
  8. Ethynylcytidine is a synthetic cytidine nucleoside containing a covalently bound ethynyl group with potential antineoplastic and radiosensitizing activities.
  9. nucleoside analog

    Cytarabine hydrochloride, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM.
  10. cNIIIB nucleotidase inhibitor

    7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor with IC50 value of 87.8????7.5??M.
  11. PNP inhibitor

    CI 972 is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent.
  12. Orotidine is an intermediate in pyrimidine nucleotide biosynthesis in RNA and DNA, and plays a crucial role in contemporary biology.
  13. 1-Methylinosine is a modified nucleotide found at position 37 in tRNA 3' to the anticodon of eukaryotic tRNA.
  14. 5-Methylcytidine is a pyrimidine nucleoside detected in multiple biofluids.
  15. Pseudouridine, the most abundant modified nucleoside in non-coding RNAs, enhances the function of transfer RNA and ribosomal RNA by stabilizing RNA structure.
  16. Isoguanine is a purine base that is an isomer of guanine. A building block in organic synthesis.
  17. 1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine is a bicyclic nucleoside.
  18. 5-Aza-7-deazaguanine is a substrate for wild-type (WT) E. coli purine nucleoside phosphorylase and its Ser90Ala mutant in the synthesis of base-modified nucleosides.
  19. Deoxypseudouridine is a nucleotide analog.
  20. seudothymidine is a C-nucleoside analog of thymidine.
  21. 2'-Deoxypseudoisocytidine is a nucleoside analogue.
  22. DMTr-LNA-5MeU-3-CED-phosphoramidite is a nucleoside derivative.
  23. Locked nucleic acid 1 is a derivative of LNA-type nucleoside.
  24. 6-Amino-5-nitropyridin-2-one is a pyridine base and used as a nucleobase of hachimoji DNA, in which it pairs with 5-aza-7-deazaguanine.
  25. Nucleoside-Analog-2 is a 4'-Azidocytidine analogue against Hepatitis C virus (HCV) replication.
  26. Nucleoside-Analog-1 is a 4??-Azidocytidine analogue against Hepatitis C virus replication.
  27. Transmethylation Inhibitor

    SIBA selectively inhibits spermine synthase, IC50=8 uM.
  28. PNP inhibitor

    Forodesine(BCX-1777 freebase; Immucillin-H) is an orally bioavailable PNP inhibitor with picomolar potency; induces apoptosis, mainly in T cells.
  29. PNP inhibitor

    Forodesine hydrochloride (BCX-1777) is a highly potent and specific purine nucleoside phosphorylase (PNP) inhibitor.
  30. 2'-Deoxycytidine hydrochloride is composed of the purine nucleoside guanine linked by its N9 nitrogen to the C1 carbon of deoxyribose.
  31. cytotoxic agent

    Rabacfosadine (GS-9219), a novel prodrug of the nucleotide analogue PMEG, is designed as a cytotoxic agent that preferentially targets lymphoid cells.
  32. Elacytarabine (CP 4055) is a lipid-conjugated derivative of the nucleoside analog cytarabine. Elacytarabine (CP 4055) is an antineoplastic drug with cytotoxicity in solid tumors.
  33. Tenofovir exalidex, also known as HDP-Tenofovir and CMX-157, is a novel lipid acyclic nucleoside phosphonate that delivers high intracellular concentrations of the active antiviral agent tenofovir.
  34. Riamilovir, also known as Triazavirin, is a nucleoside analogue of nucleic acid and an antiviral agent, works by inhibiting the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is shown active in inhibition of the tick-borne encephalitis virus reproduction (strain Sofiin) by accumulation in the SKEV cell culture.

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