Catalog No.
Product Name
Application
Product Information
Citations
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nucleoside analogue reverse transcriptase inhibitor
Zalcitabine is a potent nucleoside analogue reverse transcriptase inhibitor used in the treatment of HIV infection. -
Purine Nucleoside Analog
2'-O-Methyl-5-iodouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound can be utilized in studies aimed at understanding the biochemical pathways of cancer and the development of novel therapeutic strategies. -
SAHH inhibitor
Adenosine dialdehyde is a purine nucleoside analogue and a potent inhibitor of S-adenosylhomocysteine hydrolase (SAHH), with a Ki of 3.3 nM. By inhibiting SAHH, it disrupts methylation-dependent processes, contributing to its demonstrated anti-tumor activity in vivo. Adenosine dialdehyde is a valuable tool in cancer research, particularly in studies targeting epigenetic regulation and methylation pathways. -
Nucleoside Analog
Galocitabine is a nucleoside analog that functions primarily by inhibiting nucleic acid synthesis, leading to the suppression of cancer cell proliferation and antiviral activity. This compound exhibits notable efficacy against various cancer types and can be utilized in research focused on exploring therapeutic strategies for oncological and viral diseases. Its mechanism makes it a valuable tool in studying cellular responses and treatment pathways in cancer biology and virology. -
Nucleoside Analog
5-Hydroxymethyl-2'-deoxyuridine is a nucleoside analog that serves as an effective inhibitor of DNA replication in various human leukemia cell lines, exhibiting IC50 values ranging from 1.7 to 5.8 μM. This compound has been shown to extend the survival of mice with L1210 leukemia, demonstrating its potential in cancer treatment research. Its unique properties make it a valuable tool for investigating mechanisms of cell replication and the biology of leukemia. -
Nucleoside Antimetabolite/Analog Inhibitor
Netivudine is a nucleoside antimetabolite that acts as an analog inhibitor with significant antiviral activity against varicella zoster virus. In addition to its biological applications, Netivudine features an alkyne group, enabling its use in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc). This reagent is valuable for molecular biology research and chemical biology applications, particularly in the development of novel therapeutic agents. -
Nucleoside Analogue
2-Fluoroadenosine is a nucleoside analogue targeting adenosine kinase (ADK). It exhibits significant antiparasitic activity, with an EC50 value of 0.842 mM against Cryptosporidium parvum. This compound serves as a valuable tool in the research of parasitic diseases, facilitating studies on metabolic pathways and therapeutic interventions. -
Purine Nucleoside Analog
7-Deazaguanosine is a purine nucleoside analog that exhibits antitrypanosomal activity. This compound targets the pathways involved in nucleotide metabolism, making it useful in the study of parasitic diseases such as Trypanosomiasis. Its biological activity aids in the exploration of nucleoside analogs for therapeutic applications in infectious diseases. -
Nucleoside Analog
2'-Deoxy-2'-fluoroarabinoadenosine is a nucleoside analog that targets DNA synthesis. It demonstrates significant anticancer activity, particularly in the context of human immunodeficiency virus (HIV) research. This compound is valuable for studies involving nucleoside metabolism and the investigation of antiviral therapies. -
Nucleoside Analog
3'-O-Azidomethyl-CTP is a nucleoside analog that serves as a crucial building block for nucleic acid synthesis. It exhibits versatility in the synthesis of modified RNA and DNA, making it valuable for applications in molecular biology and genetic engineering. This compound enables researchers to incorporate azidomethyl groups into nucleic acid structures, facilitating studies in genetic function, drug development, and bioconjugation techniques. -
Nucleoside Analog
DMTr-2'-O-propyl-rC(Bz)-3'-CE-phosphoramidite is a nucleoside analog designed for use in oligonucleotide synthesis. This monomer plays a critical role in the formation of modified RNA molecules, facilitating studies in molecular biology and gene therapy applications. Its unique structure enhances stability and incorporation efficiency, making it an invaluable tool for researchers exploring nucleic acid functionality and behavior. -
Nucleoside Analog
DMTr-S-5-C-Me-2'-O-Me-rA(Bz)-3'-CE-phosphoramidite is a nucleoside analog used primarily in the synthesis of modified oligonucleotides. This phosphoramidite allows for the incorporation of modified ribonucleotides, enhancing stability and binding affinity in nucleic acid constructs. It is valuable for applications in therapeutic research, molecular biology, and gene delivery systems. -
Nucleoside Analog
m7ITP is a nucleoside analog that serves as a key monomer for nucleic acid synthesis. This compound exhibits essential properties for the development of RNA and DNA constructs, enabling detailed studies in molecular biology and genetic engineering. Its utility includes applications in the design of synthetic oligonucleotides and investigation of nucleic acid interactions. -
Nucleoside Analog
DMTr-2'-O-Me-rA(Bz)-3'-(D)-PSM-phosphoramidite is a nucleoside analog designed for efficient nucleic acid synthesis. This compound serves as a key monomer for the incorporation of modified ribonucleotides into oligonucleotides, enhancing stability and bioactivity. It is particularly useful in the development of RNA therapeutics, probes, and various molecular biology applications, facilitating precise manipulation of RNA structures. -
Nucleoside Analog
5'-OH-(2'OMe-U)pU is a nucleoside analog designed for use in nucleic acid synthesis. This compound serves as a monomeric building block, facilitating the incorporation of modified RNA structures. Its specific properties make it suitable for applications in RNA research, including the development of oligonucleotides and experimental RNA technologies. -
Nucleoside Analog
DMTr-2'-O-propyl-rA(Bz)-3'-CE-phosphoramidite is a specialized nucleoside analog designed for RNA synthesis. This phosphoramidite derivative facilitates the incorporation of modified nucleotides into RNA strands, enhancing the stability and functionality of nucleic acids. Its applications include the development of RNA-based therapeutics, probes, and biosensors, making it a valuable tool in nucleic acid research and biotechnological studies. -
Nucleoside Analog
5'-O-DMTr-2'-O-4'-C-Locked-rG(iBu) is a nucleoside analog specifically designed for use in nucleic acid synthesis. This compound functions as a protected monomer, facilitating the incorporation of modified guanosine units into oligonucleotide sequences. Its unique structural features enhance stability and enzymatic properties, making it an essential reagent for researchers focused on developing therapeutics and diagnostic tools involving RNA and DNA. -
Nucleoside Analog
2'-O-MOE-GTP is a nucleoside analog that serves as a substrate in the synthesis of oligonucleotides. Its unique substitution at the 2' position enhances the stability and binding affinity of RNA molecules. This compound is widely utilized in RNA research, including studies on RNA interference and the development of therapeutics targeting RNA-based diseases. -
Nucleoside Analog
Spacer C12 phosphoramidite is a nucleoside analog that serves as a building block for nucleic acid synthesis. This monomeric reagent enables the incorporation of spacer elements into oligonucleotide sequences, facilitating studies in molecular biology and genetics. Its unique structure allows for enhanced structural flexibility and potential applications in functionalized nucleic acids for research purposes. -
Nucleoside Analog
2',3'-Di-O-Methyladenosine is a nucleoside analog primarily utilized in nucleic acid synthesis. This compound serves as a valuable monomeric building block, facilitating the production of modified RNA and DNA. Its unique structural properties enhance the stability and functionality of nucleic acid constructs, making it an essential tool for researchers in molecular biology and genetic engineering applications. -
Nucleoside Analog
Cy3-CTP is a nucleoside analog that functions as a fluorescently labeled cytidine triphosphate. It is utilized in nucleic acid synthesis, allowing for the incorporation of Cy3 dye into RNA and DNA molecules. This compound is particularly beneficial for applications in molecular biology, including real-time PCR, in situ hybridization, and RNA imaging techniques, facilitating enhanced tracking and visualization of nucleic acids. -
Nucleoside Analog
2'-O-Propargyl-rC(Bz) is a nucleoside analog with a propargylic functionality that serves as a versatile monomer for nucleic acid synthesis. Its structure enables incorporation into RNA strands, facilitating the study of nucleic acid interactions and modifications. This compound is particularly useful in research applications involving RNA synthesis, bioconjugation, and the development of nucleic acid-based therapeutics. -
Nucleoside Analog
Pseudouridine 5'-phosphate is a nucleoside analog that serves as a key building block in nucleic acid synthesis. It is known to enhance the stability and biological activity of RNA molecules, making it a valuable reagent for studies involving RNA structure and function. This compound is frequently utilized in the development of RNA-based therapeutics and novel gene editing technologies. -
Nucleoside Analog
5-Formyl-Dctp is a nucleoside analog exhibiting structural properties that enable its incorporation into DNA during synthesis. This compound serves as a vital intermediate in the preparation of modified nucleotides, facilitating studies in nucleic acid research and synthetic biology. Its unique aldehyde functional group allows for further chemical modifications, making it useful in various applications, including the development of labeled oligonucleotides and probes for genomic studies. -
Nucleoside Analog
3'-O-NH2-2'-dA is a nucleoside analog that serves as a crucial building block for nucleic acid synthesis. It displays unique biochemical properties that facilitate the incorporation of amino groups into nucleic acid sequences, enhancing the versatility of synthetic oligonucleotides. This compound is essential for research applications involving genetic engineering, molecular diagnostics, and the development of novel therapeutic agents. -
Nucleoside Analog
(2'OMe-5'p-U)pU is a nucleoside analog that serves as a monomeric building block for nucleic acid synthesis. Its unique structural modifications enhance stability and binding affinity, making it a valuable tool for researchers in the fields of molecular biology and genetic engineering. This compound can be utilized in the development of oligonucleotides and other nucleic acid-based applications, providing insights into RNA structure and function. -
Nucleoside Analog
5'-O-DMTr-2'-O-4'-C-locked-5-Me-rC(Bz) is a nucleoside analog designed for use in nucleic acid synthesis. This compound features modifications that enhance stability and potential for incorporation into oligonucleotides. Its unique structural properties make it valuable for research applications involving RNA chemistry and the development of novel therapeutics. -
Nucleoside Analog
N1-Me-pUMP is a nucleoside analog that serves as a monomeric building block for nucleic acid synthesis. This reagent is essential for the preparation of modified oligonucleotides and plays a pivotal role in studies involving RNA and DNA characterization. Its incorporation into nucleic acid sequences can facilitate research in areas such as gene expression, molecular diagnostics, and therapeutic development. -
Nucleoside Analog
N6-Benzoyl-2'-O,4'-C-methyleneadenosine is a nucleoside analog that serves as a key building block in nucleic acid synthesis. Its unique structural modifications enhance incorporation into RNA and DNA sequences, facilitating the study of nucleic acid functioning and interactions. This compound is valuable for research in molecular biology, enabling investigations into gene expression, replication mechanisms, and therapeutic applications. -
Nucleoside Analog
(2'OMe-5'p-A)pU is a nucleoside analog designed for use in nucleic acid synthesis. This modified nucleotide contains a 2'-O-methyl group, enhancing its stability and affinity for complementary bases. It serves as a useful building block in the development of oligonucleotides for research applications including gene expression studies, antisense oligonucleotide design, and therapeutic development. -
Nucleoside Analog
CTPαS is a nucleoside analog that serves as a phosphonate monomer for nucleic acid synthesis. Its structural properties enable incorporation into RNA and DNA, facilitating the study of nucleic acid function and dynamics. This reagent is highly valuable in biochemical research, particularly in the development of oligonucleotide therapeutics and molecular biology applications. -
Nucleoside Analog
DMTr-2'-O-Bn-rG(iBu)-3'-CE-phosphoramidite is a nucleoside analog designed for use in nucleic acid synthesis. This compound serves as a monomeric raw material, facilitating the incorporation of modified ribonucleotides into oligonucleotides. It is particularly valuable for applications involving the synthesis of RNA molecules, enabling research in fields such as molecular biology, genetics, and therapeutic development. -
Nucleoside Analog
Pyrrolo-dCTP is a nucleoside analog that serves as a monomeric raw material for nucleic acid synthesis. This compound is instrumental in the development of modified oligonucleotides, enabling enhanced stability and improved properties for various biochemical applications. Pyrrolo-dCTP is particularly valuable in studies focused on gene editing, antisense therapies, and other nucleic acid-based research methodologies. -
Nucleoside Analog
Cbz-TRIS-PDA trihydrochloride is a trifunctional nucleoside analog featuring a Cbz protecting group, designed for use in oligonucleotide synthesis. This compound serves as a valuable reagent for modifying nucleic acids, facilitating the development of advanced therapeutic agents and research tools. Its unique properties enhance the efficiency and specificity of synthesis processes, making it an essential resource for molecular biology applications. -
Nucleoside Analog
DMTr-5-Me-dC(C6-O-Lev)-3'-CE-phosphoramidite is a nucleoside analog that serves as a versatile building block for the synthesis of oligonucleotides. This modified phosphoramidite facilitates the incorporation of specific structural elements into nucleic acid sequences. Its unique properties make it suitable for applications in molecular biology, including the development of therapeutic nucleic acids and probes for gene expression studies. -
Nucleoside Analog
5-Methoxyuridine-5'-triphosphate is a nucleoside analog that acts as a building block for nucleic acid synthesis. This compound exhibits key biological activity by incorporating into RNA, thus facilitating the study of RNA dynamics and function. It is useful for applications in molecular biology and genetic research, including the development of RNA-based therapeutics and assays. -
Nucleoside Analog
DMTr-2'-O-TBDMS-8-azanebularine-3'-CE-phosphoramidite is a nucleoside analog designed for use in nucleic acid synthesis. This phosphoramidite monomer facilitates the incorporation of modified nucleotides into oligonucleotide sequences, enhancing the stability and functionality of nucleic acids. It is particularly valuable in the development of antisense oligonucleotides and RNA-based therapeutics. -
Nucleoside Analog
5'-O-DMTr-3'-β-OH-2'-5-Me-dU(Boc) is a nucleoside analog utilized in nucleic acid synthesis. This compound serves as a monomeric building block, facilitating the development of modified oligonucleotides. Its unique structural features enhance the properties of nucleic acids for research applications in gene expression studies and therapeutic development. -
Nucleoside Analog
DMTr-2'-O-TBDMS-5-F-rU-3'-CE-phosphoramidite is a nucleoside analog designed for use in nucleic acid synthesis. This phosphoramidite monomer facilitates the incorporation of modified nucleotides into oligonucleotides, enabling the study of nucleic acid structure and function. Its unique chemical properties allow researchers to explore various applications in genetics, molecular biology, and therapeutic development. -
Nucleoside Analog
3'-O-Azidomethyl-ATP is a nucleoside analog that serves as a monomeric building block for nucleic acid synthesis. Its azide functional group allows for further click chemistry applications, enabling the introduction of various functionalities into nucleic acids. This reagent is essential for research in genetic engineering, synthetic biology, and the development of novel therapeutics. -
Nucleoside Antimetabolite/Analog
7,9-Dimethylguanine is a nucleoside antimetabolite and analog that represents a modified nucleotide base formed during RNA degradation. It serves as a valuable biomarker for assessing the severity of alcoholic liver disease (ALD), with its levels in urine and serum providing critical insights into disease progression. This compound is pertinent in research related to metabolic disorders and liver function assessment. -
Nucleoside Analog
LNA-UTP is a nucleoside analog that serves as a key building block in the synthesis of oligonucleotides. It enhances the thermal stability and specificity of nucleic acid sequences, making it invaluable for applications in molecular biology, including gene expression analysis and antisense oligonucleotide design. Its unique properties support research in areas such as RNA interference and the development of diagnostic tools. -
Nucleoside Analog
DMTr-2'-O-Me-rA(Bz)-3'-(D)-DPSE-phosphoramidite is a nucleoside analog that serves as a key monomer for the synthesis of modified nucleic acids. This reagent is specifically designed to enhance the stability and efficacy of RNA oligonucleotides, making it invaluable for applications in antisense research, siRNA development, and other RNA-based therapeutics. Its unique structure contributes to the creation of oligonucleotides with improved pharmacological properties. -
Nucleoside Analog
O6-Me-GTP is a nucleoside analog that serves as a critical monomer for the synthesis of nucleic acids. This compound can be incorporated into RNA and DNA, facilitating studies on nucleotide function and nucleic acid interactions. It is valuable for applications in genetic research, molecular biology, and therapeutic exploration. -
Nucleoside Analog
DMT-2'-O-MOE-Tr is a nucleoside analog featuring a dimethoxytrityl (DMT) protecting group. This compound plays a crucial role in the synthesis of nucleic acids, facilitating the incorporation of modified nucleotides into oligonucleotides. Its unique structure enhances stability and solubility, making it suitable for various applications in chemical biology and genomics research. -
Nucleoside Analog
3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)uridine is a nucleoside analog that serves as a valuable monomeric substrate for nucleic acid synthesis. Its unique siloxane linkage enhances the stability and solubility of nucleotides in various biochemical applications. This compound is ideal for researchers engaged in synthetic biology, genetic engineering, and the development of RNA-based therapeutics. -
Nucleoside Analog
3'-O-NH2-2'-dC is a nucleoside analog that serves as a valuable monomer for nucleic acid synthesis. This compound effectively incorporates into oligonucleotides, enabling the exploration of RNA and DNA functionalities. It is utilized in various research applications, including the study of gene expression, antisense technology, and the development of novel therapeutic strategies. -
Nucleoside Analog
dATPαS (2'-Deoxyadenosine 5'-O-(1-thiotriphosphate)) is a nucleoside analog that mimics natural dATP in biochemical processes. It serves as a building block for nucleic acid synthesis, facilitating the incorporation of sulfur into RNA and DNA strands. This compound is widely used in studies involving nucleotide metabolism, gene expression, and the development of molecular probes. -
Nucleoside Analog
DMTr-S-5-C-Me-2'-O-Me-rU-3'-CE-phosphoramidite is a nucleoside analog utilized in oligodeoxynucleotide synthesis. This phosphoramidite derivative facilitates the incorporation of modified uridine residues into nucleic acids, enabling enhanced stability and biochemical properties. It serves as a valuable tool in genetic research, antisense oligonucleotide development, and the exploration of RNA functionalities. -
Nucleoside Analog
5'-O-DMTr-3'-NH₂-2'-O-Me-dU is a nucleoside analog designed for use in nucleic acid synthesis. This compound serves as a monomeric building block, facilitating the incorporation of modified nucleotides into oligonucleotides. Its unique structure enhances the stability and functionality of nucleic acids, making it a valuable tool in molecular biology research. Potential applications include RNA synthesis, bioconjugation, and the development of therapeutic oligonucleotides.
