2-(Azido-PEG3-amido)-1,3-bis(NHS ester) is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) applications. This compound features an azide functional group which allows for versatile click chemistry reactions, including copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. It is instrumental in the synthesis of targeted protein degraders, facilitating effective drug development and biological research studies.
2-(Azido-PEG3-amido)-1,3-bis(NHS ester) is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) applications. This compound features an azide functional group which allows for versatile click chemistry reactions, including copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. It is instrumental in the synthesis of targeted protein degraders, facilitating effective drug development and biological research studies.
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