2′-Deoxy-5-nitrocytidine

Catalog No.: A57717
DNA Methyltransferase Inhibitor
2′-Deoxy-5-nitrocytidine is a potent inhibitor of DNA methyltransferase, disrupting the methylation process crucial for gene expression regulation. This compound is primarily utilized in cancer research to investigate its effects on tumorigenesis and cellular differentiation. By modulating DNA methylation patterns, it provides valuable insights into epigenetic modifications and their implications in various malignancies.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description2′-Deoxy-5-nitrocytidine is a potent inhibitor of DNA methyltransferase, disrupting the methylation process crucial for gene expression regulation. This compound is primarily utilized in cancer research to investigate its effects on tumorigenesis and cellular differentiation. By modulating DNA methylation patterns, it provides valuable insights into epigenetic modifications and their implications in various malignancies.
Product Information
Catalog NumA57717
FormulaC9H12N4O6
Molecular Weight272.21
CAS Number69100-02-3
SMILESO=C1N(C=C(C(N)=N1)[N+]([O-])=O)[C@]2([H])O[C@@H]([C@H](C2)O)CO
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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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