2-Hydroxyisobutyric acid (2-HIBA) is a selective modulator of the Insulin/IGF-1 signaling pathway and p38 MAPK pathway, known for its ability to decrease reactive oxygen species and fat accumulation in Caenorhabditis elegans. This compound enhances β-oxidation while suppressing fatty acid synthesis via upregulation of SKN-1/NRF2 and downregulation of SREBP-1c transcription factors. 2-HIBA exhibits notable anti-aging and lipid-lowering properties, making it valuable for investigating metabolic diseases, including obesity and diabetes. Additionally, it serves as a renewable precursor for methacrylate production through 2-HIB-CoA mutase-mediated biosynthesis.
2-Hydroxyisobutyric acid (2-HIBA) is a selective modulator of the Insulin/IGF-1 signaling pathway and p38 MAPK pathway, known for its ability to decrease reactive oxygen species and fat accumulation in Caenorhabditis elegans. This compound enhances β-oxidation while suppressing fatty acid synthesis via upregulation of SKN-1/NRF2 and downregulation of SREBP-1c transcription factors. 2-HIBA exhibits notable anti-aging and lipid-lowering properties, making it valuable for investigating metabolic diseases, including obesity and diabetes. Additionally, it serves as a renewable precursor for methacrylate production through 2-HIB-CoA mutase-mediated biosynthesis.
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