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2’-O-Acetyl-3’-azido-5’-O-(4-methylbenzoyl)-3’-deoxyuridine

Purine Nucleoside Analog

2’-O-Acetyl-3’-azido-5’-O-(4-methylbenzoyl)-3’-deoxyuridine is a purine nucleoside analog that demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, facilitating its efficacy in cancer research. Additionally, this compound serves as a versatile click chemistry reagent due to its azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules, DBCO, or BCN groups. This makes it a valuable tool for bioconjugation and molecular labeling studies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	256485-42-4
Applications	Purine Nucleoside Analog
Formula	C₁₉H₁₉N₅O₇
Molecular Weight	429.38
SMILES	O=C(C1=CC=C(C)C=C1)OC[C@@H]2[C@@H](N=[N+]=[N-])[C@@H](OC(C)=O)[C@H](N3C(NC(C=C3)=O)=O)O2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.