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2'-O-TBDMS-Paclitaxel

Catalog No.: A54923
Paclitaxel Derivative
2'-O-TBDMS-Paclitaxel is a derivative of the well-known chemotherapeutic agent Paclitaxel, with the 2'-hydroxyl group protected as a tert-butyldimethylsilyl (TBDMS) ether. This modification enhances the compound's stability and solubility, making it suitable for various chemical biology applications. 2'-O-TBDMS-Paclitaxel serves as a valuable tool in cancer research, particularly in studies focusing on drug delivery systems and the development of novel therapeutics.
2'-O-TBDMS-Paclitaxel 114655-02-6 Paclitaxel Derivative
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description2'-O-TBDMS-Paclitaxel is a derivative of the well-known chemotherapeutic agent Paclitaxel, with the 2'-hydroxyl group protected as a tert-butyldimethylsilyl (TBDMS) ether. This modification enhances the compound's stability and solubility, making it suitable for various chemical biology applications. 2'-O-TBDMS-Paclitaxel serves as a valuable tool in cancer research, particularly in studies focusing on drug delivery systems and the development of novel therapeutics.
Product Information
Catalog NumA54923
FormulaC53H65NO14Si
Molecular Weight968.17
CAS Number114655-02-6
SMILESCC(O[C@]12[C@@]3([H])[C@@H]([C@]4(C(C)(C([C@H](C([C@@]3([C@H](C[C@@]1([H])OC2)O)C)=O)OC(C)=O)=C([C@H](C4)OC([C@H](O[Si](C)(C)C(C)(C)C)[C@H](C5=CC=CC=C5)NC(C6=CC=CC=C6)=O)=O)C)C)O)OC(C7=CC=CC=C7)=O)=O
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Cytoskeleton > Microtubule/Tubulin