2-Oxokolavenol is a selective agonist of the farnesoid X receptor (FXR), demonstrating an EC50 of approximately 3.7 μM. This compound mitigates acetaminophen-induced hepatocyte damage through an FXR-dependent mechanism, facilitating the recruitment of co-activators and enhancing FXR transcriptional activity. Derived from the plant Aglaia spectabilis, 2-Oxokolavenol is valuable for research on liver diseases and the underlying mechanisms of FXR signaling.
2-Oxokolavenol is a selective agonist of the farnesoid X receptor (FXR), demonstrating an EC50 of approximately 3.7 μM. This compound mitigates acetaminophen-induced hepatocyte damage through an FXR-dependent mechanism, facilitating the recruitment of co-activators and enhancing FXR transcriptional activity. Derived from the plant Aglaia spectabilis, 2-Oxokolavenol is valuable for research on liver diseases and the underlying mechanisms of FXR signaling.
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