2B-(SP)

Catalog No.: A44142
GSK-3 Substrate
2B-(SP) is an eIF2B-based substrate specifically designed for glycogen synthase kinase-3 (GSK-3). It exhibits efficient phosphorylation by both GSK-3α and GSK-3β isoforms, making it a valuable tool for studying GSK-3-related signaling pathways and cellular processes. This compound is suitable for research applications involving protein phosphorylation and GSK-3 activity modulation.
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Size Price Stock Qty
1mg
$355.00
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description2B-(SP) is an eIF2B-based substrate specifically designed for glycogen synthase kinase-3 (GSK-3). It exhibits efficient phosphorylation by both GSK-3α and GSK-3β isoforms, making it a valuable tool for studying GSK-3-related signaling pathways and cellular processes. This compound is suitable for research applications involving protein phosphorylation and GSK-3 activity modulation.
Product Information
Catalog NumA44142
FormulaC71H123N26O29P
Molecular Weight1835.87
CAS Number186901-17-7
SequenceArg-Arg-Ala-Ala-Glu-Glu-Leu-Asp-Ser-Arg-Ala-Gly-{Ser(PO3H2)}-Pro-Gln-Leu
Sequence shorteningRRAAEELDSRAG-{Ser(PO3H2)}-PQL
SMILESC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(=N)N)N)=O)CCCNC(=N)N)=O)C)=O)C)=O)CCC(O)=O)=O)CCC(O)=O)=O)CC(C)C)=O)CC(O)=O)=O)CO)=O)CCCNC(=N)N)=O)C)=O)=O)COP(=O)(O)O)(=O)N1[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CCC(N)=O)=O)CCC1
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