3-(2-(4-Methylpiperazin-1-yl)ethyl)azetidin-3-ol serves as a versatile linker in PROTAC applications, specifically designed for the targeted degradation of BRD4, exemplified by the BRD4 PROTAC BD-9136. This compound facilitates the formation of bifunctional molecules that promote the ubiquitination and subsequent proteasomal degradation of BRD4. Its structural features enable efficient engagement with target proteins, making it valuable in research focused on protein regulation and therapeutic discovery.
3-(2-(4-Methylpiperazin-1-yl)ethyl)azetidin-3-ol serves as a versatile linker in PROTAC applications, specifically designed for the targeted degradation of BRD4, exemplified by the BRD4 PROTAC BD-9136. This compound facilitates the formation of bifunctional molecules that promote the ubiquitination and subsequent proteasomal degradation of BRD4. Its structural features enable efficient engagement with target proteins, making it valuable in research focused on protein regulation and therapeutic discovery.
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