3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)propanoic acid

Catalog No.: A82256
PROTAC Linker
3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)propanoic acid serves as a PROTAC linker, facilitating the creation of proteolysis-targeting chimeras (PROTACs). This compound enables the selective degradation of target proteins by promoting the recruitment of E3 ligases. Its application is pivotal in the development of novel therapeutics aimed at addressing various diseases by modulating protein levels within biological systems.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)propanoic acid serves as a PROTAC linker, facilitating the creation of proteolysis-targeting chimeras (PROTACs). This compound enables the selective degradation of target proteins by promoting the recruitment of E3 ligases. Its application is pivotal in the development of novel therapeutics aimed at addressing various diseases by modulating protein levels within biological systems.
Product Information
Catalog NumA82256
FormulaC24H21NO4
Molecular Weight387.44
CAS Number882847-07-6
SMILESO=C(OCC1C=2C=CC=CC2C=3C=CC=CC31)NC4=CC=C(C=C4)CCC(=O)O
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