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3’-Azido-3’-deoxy-5-fluoro-beta-L-uridine

Purine Nucleoside Analog

3'-Azido-3'-deoxy-5-fluoro-beta-L-uridine is a purine nucleoside analog that demonstrates significant antitumor activity, primarily against indolent lymphoid malignancies. Its mechanisms of action involve inhibition of DNA synthesis and induction of apoptosis. Additionally, this compound serves as a versatile click chemistry reagent, featuring an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules, including those with DBCO or BCN groups. These properties make it a valuable tool for various biochemical research applications.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2095417-40-4
Applications	Purine Nucleoside Analog
Formula	C₉H₁₀FN₅O₅
Molecular Weight	287.20
SMILES	O[C@H]1[C@@H](N=[N+]=[N-])[C@H](CO)O[C@@H]1N2C=C(F)C(NC2=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.