3’-Azido-3’-deoxy-5-iodouridine is a purine nucleoside analog that targets DNA synthesis pathways to exhibit antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer effects are primarily mediated through inhibition of DNA replication and the induction of apoptosis. Additionally, this compound serves as a versatile click chemistry reagent, featuring an azide group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne, DBCO, or BCN-functionalized molecules. This makes it a valuable tool for bioconjugation applications in chemical biology research.
3’-Azido-3’-deoxy-5-iodouridine is a purine nucleoside analog that targets DNA synthesis pathways to exhibit antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer effects are primarily mediated through inhibition of DNA replication and the induction of apoptosis. Additionally, this compound serves as a versatile click chemistry reagent, featuring an azide group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne, DBCO, or BCN-functionalized molecules. This makes it a valuable tool for bioconjugation applications in chemical biology research.
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