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3’-Azido-3’-deoxy-5-iodouridine

Purine Nucleoside Analog

3’-Azido-3’-deoxy-5-iodouridine is a purine nucleoside analog that targets DNA synthesis pathways to exhibit antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer effects are primarily mediated through inhibition of DNA replication and the induction of apoptosis. Additionally, this compound serves as a versatile click chemistry reagent, featuring an azide group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne, DBCO, or BCN-functionalized molecules. This makes it a valuable tool for bioconjugation applications in chemical biology research.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2072145-33-4
Applications	Purine Nucleoside Analog
Formula	C₉H₁₀IN₅O₅
Molecular Weight	395.11
SMILES	OC[C@@H]1[C@@H](N=[N+]=[N-])[C@@H](O)[C@H](N2C(NC(C(I)=C2)=O)=O)O1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.