3’-Azido-3’-deoxy-5-methyluridine is a purine nucleoside analog primarily effective in inhibiting DNA synthesis, which promotes apoptosis in cancer cells. Its broad antitumor activity is particularly relevant for indolent lymphoid malignancies. Additionally, this compound serves as a click chemistry reagent, featuring an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, facilitating various biochemical applications in research.
3’-Azido-3’-deoxy-5-methyluridine is a purine nucleoside analog primarily effective in inhibiting DNA synthesis, which promotes apoptosis in cancer cells. Its broad antitumor activity is particularly relevant for indolent lymphoid malignancies. Additionally, this compound serves as a click chemistry reagent, featuring an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, facilitating various biochemical applications in research.
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