3-Methylcrotonyl CoA is an endogenous metabolite that serves as a critical intermediate in the leucine catabolism pathway. It is converted to 3-Methylglutaconyl CoA via the enzyme 3-Methylcrotonyl CoA Carboxylase. Accumulation of 3-Methylglutaconyl CoA due to mutations in 3-Methylglutaconyl-CoA Hydratase can result in metabolic disorders, such as 3MGA-uria. This compound is valuable for investigating metabolic diseases linked to disruptions in the leucine degradation pathway.
3-Methylcrotonyl CoA is an endogenous metabolite that serves as a critical intermediate in the leucine catabolism pathway. It is converted to 3-Methylglutaconyl CoA via the enzyme 3-Methylcrotonyl CoA Carboxylase. Accumulation of 3-Methylglutaconyl CoA due to mutations in 3-Methylglutaconyl-CoA Hydratase can result in metabolic disorders, such as 3MGA-uria. This compound is valuable for investigating metabolic diseases linked to disruptions in the leucine degradation pathway.
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