4-Hydroxyderricin is a selective inhibitor of Monoamine Oxidase B (MAO-B) with an IC50 of 3.43 μM, making it a valuable tool for studying neurological conditions. In addition to its primary mechanism, it exhibits mild inhibition of dopamine β-hydroxylase activity. This compound has demonstrated a range of biological activities, including antidepressant, anti-allergic, anti-diabetic, antioxidant, and antitumor effects. It has been shown to induce apoptosis and cell cycle arrest in hepatocellular carcinoma cells via modulation of the PI3K/AKT/mTOR pathway, as well as enhance osteoblast differentiation while inhibiting osteoclast formation, positioning it as a promising candidate for research into inflammatory diseases.
4-Hydroxyderricin is a selective inhibitor of Monoamine Oxidase B (MAO-B) with an IC50 of 3.43 μM, making it a valuable tool for studying neurological conditions. In addition to its primary mechanism, it exhibits mild inhibition of dopamine β-hydroxylase activity. This compound has demonstrated a range of biological activities, including antidepressant, anti-allergic, anti-diabetic, antioxidant, and antitumor effects. It has been shown to induce apoptosis and cell cycle arrest in hepatocellular carcinoma cells via modulation of the PI3K/AKT/mTOR pathway, as well as enhance osteoblast differentiation while inhibiting osteoclast formation, positioning it as a promising candidate for research into inflammatory diseases.
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