4-Methyl erlotinib is a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. This compound effectively disrupts EGF-mediated tumor cell proliferation by significantly lowering EGFR-specific tyrosine phosphorylation levels. In preclinical studies utilizing a mouse model of human tumor transplantation, 4-Methyl erlotinib exhibited notable and prolonged inhibition of EGFR phosphotyrosine levels, leading to substantial growth inhibition in EGFR-dependent human malignancies.
4-Methyl erlotinib is a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. This compound effectively disrupts EGF-mediated tumor cell proliferation by significantly lowering EGFR-specific tyrosine phosphorylation levels. In preclinical studies utilizing a mouse model of human tumor transplantation, 4-Methyl erlotinib exhibited notable and prolonged inhibition of EGFR phosphotyrosine levels, leading to substantial growth inhibition in EGFR-dependent human malignancies.
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