4-Oxo Docosahexaenoic Acid is a potent PPARγ agonist with notable antiproliferative properties. This compound effectively inhibits the growth of several triple-negative breast cancer cell lines, such as MDA-MB-231 and BT549, at concentrations of 50-100 μM, although it shows increased proliferation in MCF-7 cells. It covalently binds to PPARγ, activating gene transcription, as demonstrated in luciferase reporter assays and dendritic cells, with an EC50 of approximately 8-16 μM. This makes 4-Oxo DHA a valuable tool for research into cancer biology and PPARγ-associated pathways.
4-Oxo Docosahexaenoic Acid is a potent PPARγ agonist with notable antiproliferative properties. This compound effectively inhibits the growth of several triple-negative breast cancer cell lines, such as MDA-MB-231 and BT549, at concentrations of 50-100 μM, although it shows increased proliferation in MCF-7 cells. It covalently binds to PPARγ, activating gene transcription, as demonstrated in luciferase reporter assays and dendritic cells, with an EC50 of approximately 8-16 μM. This makes 4-Oxo DHA a valuable tool for research into cancer biology and PPARγ-associated pathways.
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