4EGI-1
4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 uM.
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Biological Activity
| Discription | 4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 uM. | ||
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Product Information
| Catalog Num | A14199 |
|---|---|
| Formula | C18H12Cl2N4O4S |
| Molecular Weight | 451.28 |
| CAS Number | 315706-13-9 |
| SMILES | C1=CC=C(C(=C1)CC(=NNC2=NC(=CS2)C3=CC(=C(C=C3)Cl)Cl)C(=O)O)[N+](=O)[O-] |
| Synonyms | 4EGI1, 4EGI 1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Solubility
| In vitro (25°C) | DMSO | 79 mg/mL (175.06 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5%DMSO+pbs | 3 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.16 mL | 110.8 mL | 221.59 mL |
| 0.5 mM | 4.43 mL | 22.16 mL | 44.32 mL |
| 1 mM | 2.22 mL | 11.08 mL | 22.16 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.43 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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