4EGI-1

Catalog No.: A14199

eIF4E/eIF4G inhibitor

4EGI-1

4EGI-1 Chemical Structure

CAS NO. 315706-13-9

4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 uM.

Availability: In stock

Package Price Qty
10 mg
$120.00
25 mg
$220.00
50 mg
$350.00
10mM * 1mL in DMSO
$113.00
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Biological Activity

4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 uM.
Targets
eIF4E/eIF4G
25 μM(Kd)
In vitro (25°C) DMSO 79 mg/mL (175.06 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5%DMSO+pbs 3 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.16 mL 110.8 mL 221.59 mL
0.5 mM 4.43 mL 22.16 mL 44.32 mL
1 mM 2.22 mL 11.08 mL 22.16 mL
5 mM 0.44 mL 2.22 mL 4.43 mL

*The above data is based on the productmolecular weight 451.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14199
Actions Inhibitor
CAS No. 315706-13-9
Formula C18H12Cl2N4O4S
M. Wt 451.28
Purity >98%
Synonyms 4EGI1, 4EGI 1
SMILES C1=CC=C(C(=C1)CC(=NNC2=NC(=CS2)C3=CC(=C(C=C3)Cl)Cl)C(=O)O)[N+](=O)[O-]
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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