5,6-Dihydro-5-Fluorouracil, a metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil, acts by inhibiting the activity of dihydropyrimidine dehydrogenase (DPD). This compound exhibits cytotoxic effects on HaCaT keratinocytes, with an IC50 value of 13.5 μM. In preclinical studies, intravenous administration of 5,6-Dihydro-5-Fluorouracil in combination with 5-fluorouracil and the DPD inhibitor eniluracil has demonstrated the ability to impede tumor growth in a rat colon cancer model, highlighting its potential in cancer research applications.
5,6-Dihydro-5-Fluorouracil, a metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil, acts by inhibiting the activity of dihydropyrimidine dehydrogenase (DPD). This compound exhibits cytotoxic effects on HaCaT keratinocytes, with an IC50 value of 13.5 μM. In preclinical studies, intravenous administration of 5,6-Dihydro-5-Fluorouracil in combination with 5-fluorouracil and the DPD inhibitor eniluracil has demonstrated the ability to impede tumor growth in a rat colon cancer model, highlighting its potential in cancer research applications.
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