5-Fluoro-2'-deoxycytidine (FdCyd) is a fluoropyrimidine nucleoside analogue that functions as a DNA methyltransferase (DNMT) inhibitor. It also serves as a tumor-selective prodrug of 5-fluoro-2′-dUMP, a thymidylate synthase inhibitor. FdCyd induces cell cycle arrest in tumor cells by activating the DNA damage response and exhibits potent anti-tumor activity, making it a promising agent in epigenetic and chemotherapeutic cancer research.
5-Fluoro-2'-deoxycytidine (FdCyd) is a fluoropyrimidine nucleoside analogue that functions as a DNA methyltransferase (DNMT) inhibitor. It also serves as a tumor-selective prodrug of 5-fluoro-2′-dUMP, a thymidylate synthase inhibitor. FdCyd induces cell cycle arrest in tumor cells by activating the DNA damage response and exhibits potent anti-tumor activity, making it a promising agent in epigenetic and chemotherapeutic cancer research.
Product Information
Catalog Num
A24345
Formula
C9H12FN3O4
Molecular Weight
245.21
CAS Number
10356-76-0
SMILES
O[C@H]1C[C@H](N2C(N=C(N)C(F)=C2)=O)O[C@@H]1CO
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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