(5aS,6R,6aR)-MK-8666 functions as a selective agonist of the GPR40 receptor, primarily targeting pancreatic β cells and intestinal enteroendocrine cells to enhance fatty acid-induced insulin secretion. This compound has been investigated for its potential in the treatment of type 2 diabetes, demonstrating significant reductions in blood glucose levels. Despite its therapeutic promise, development ceased during Phase I clinical trials due to concerns regarding liver safety.
(5aS,6R,6aR)-MK-8666 functions as a selective agonist of the GPR40 receptor, primarily targeting pancreatic β cells and intestinal enteroendocrine cells to enhance fatty acid-induced insulin secretion. This compound has been investigated for its potential in the treatment of type 2 diabetes, demonstrating significant reductions in blood glucose levels. Despite its therapeutic promise, development ceased during Phase I clinical trials due to concerns regarding liver safety.
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