6-((2-((Tert-butoxycarbonyl)amino)ethyl)amino)-6-oxohexanoic acid

Catalog No.: A84381
PROTAC Linker
6-((2-((Tert-butoxycarbonyl)amino)ethyl)amino)-6-oxohexanoic acid is a chemical compound designed as a PROTAC (proteolysis-targeting chimera) linker. This linker facilitates the conjugation of ligands to E3 ligases, enabling targeted protein degradation. Its applications primarily lie in drug discovery and development, particularly in the study of protein interactions and degradation pathways. Researchers utilize this compound to create innovative therapeutic strategies by harnessing the cellular ubiquitin-proteasome system.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description6-((2-((Tert-butoxycarbonyl)amino)ethyl)amino)-6-oxohexanoic acid is a chemical compound designed as a PROTAC (proteolysis-targeting chimera) linker. This linker facilitates the conjugation of ligands to E3 ligases, enabling targeted protein degradation. Its applications primarily lie in drug discovery and development, particularly in the study of protein interactions and degradation pathways. Researchers utilize this compound to create innovative therapeutic strategies by harnessing the cellular ubiquitin-proteasome system.
Product Information
Catalog NumA84381
FormulaC13H24N2O5
Molecular Weight288.34
CAS Number1697868-59-9
SMILESO=C(OC(C)(C)C)NCCNC(=O)CCCCC(=O)O
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