Catalog No.
Product Name
Application
Product Information
Citations
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β-Adrenergic Receptor Blocker
Sotalol hydrochloride is a non-selective β-adrenergic receptor blocker that exhibits potent antiarrhythmic activity. It is utilized in research focused on pediatric arrhythmias and demonstrates efficacy by blocking β-receptors and the potassium channel KCNH2. Additionally, Sotalol hydrochloride holds potential applications as an antiepileptic agent, facilitating further studies into its diverse pharmacological effects. -
β-Adrenergic Antagonist
Levobetaxolol hydrochloride is a selective β-adrenergic antagonist primarily used in the treatment of ocular hypertension. This compound effectively reduces intraocular pressure, making it valuable for research related to glaucoma and other eye disorders. Investigations into its pharmacological profile can advance understanding of adrenergic receptor modulation in ocular applications. -
Adrenergic Receptor Antagonist
Tolazoline hydrochloride is an α-adrenergic receptor antagonist that effectively inhibits noradrenaline-induced smooth muscle contraction. This compound modulates vascular resistance, increases arterial pressure, and serves as an intervention for bradycardia and tachypnea. Tolazoline hydrochloride is utilized in research focused on erectile dysfunction, α2-adrenergic receptor agonist-related poisoning, and skin vascular diseases, making it a valuable tool for studying vascular responses and related pathologies. -
Endogenous Metabolite
Tyramine is an endogenous metabolite primarily involved in the regulation of blood pressure through its interaction with adrenergic receptors. It plays a significant role in neurotransmission and the modulation of vascular tone. Research applications of tyramine include studies focused on cardiovascular physiology, neurochemistry, and the exploration of dietary impacts on health. -
β-Adrenergic Receptor Agonist
Methoxyphenamine hydrochloride is a selective β-adrenergic receptor agonist that acts primarily as a bronchodilator. This compound enhances airway patency by relaxing bronchial smooth muscle, making it beneficial in the management of respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). Its application in research focuses on studying β-adrenergic signaling pathways and pharmacological responses in respiratory physiology. -
β-adrenergic Receptors Agonist
Isoetharine mesylate is a selective agonist of β-adrenergic receptors, exhibiting oral bioactivity. By promoting the production of cyclic AMP (cAMP), it facilitates the relaxation of smooth muscle cells. Isoetharine mesylate is primarily utilized in research related to respiratory conditions, including emphysema and bronchitis, where it serves as a bronchodilator to aid in airway relaxation and improved airflow. -
α-Adrenergic Agonist
Metaraminol tartrate is an α-adrenergic agonist that functions primarily as a vasopressor agent. This sympathomimetic amine exerts its effects by directly and indirectly stimulating adrenergic receptors, with a predominant activity on alpha receptors. It is utilized in research applications involving cardiovascular physiology and the modulation of vascular tone. -
β1/α1-adrenergic Receptor Antagonist
Bevantolol hydrochloride is a selective β1 and α1-adrenergic receptor antagonist. With pKi values of 7.83 for the β1 receptor and 6.9 for the α1 receptor in rat cerebral cortex, it demonstrates significant antagonistic activity. Additionally, Bevantolol hydrochloride exhibits potent calcium (Ca2+) antagonism, making it a valuable tool for research applications in cardiovascular studies and related therapeutic areas. -
Adrenaline Antagonists
Prazosin is an α-adrenergic receptor antagonist primarily targeting adrenaline pathways. It exhibits significant biological activity in reducing inflammation, alleviating anxiety and panic, and preventing cognitive decline associated with Alzheimer's disease. Additionally, Prazosin modulates the analgesic effects of opioids, making it a valuable compound for research applications in hypertension and neurodegenerative disorders. -
Adrenergic Receptor Agonist
Norepinephrine tartrate is a potent adrenergic receptor agonist, primarily targeting α1, α2, and β1 receptors. Its key biological activity involves regulating vascular tone, heart rate, and metabolic processes. This compound is widely utilized in cardiovascular research, particularly in studies related to blood pressure modulation and the sympathetic nervous system's roles in various physiological conditions. -
Adrenergic Receptor
Methoxyphenamine is a β-adrenergic receptor agonist belonging to the amphetamine class, primarily utilized as a bronchodilator. This compound demonstrates significant biological activity in promoting airway smooth muscle relaxation, making it useful in the treatment of bronchial constriction. Its applications extend to research in respiratory diseases and the pharmacological modulation of adrenergic pathways. -
β-agonist
Isoetharine hydrochloride is a selective, short-acting β-agonist primarily used as a bronchodilator. Its ability to stimulate β-adrenergic receptors makes it important for research applications involving respiratory therapies and inhalation studies. This compound aids in the exploration of therapeutic strategies for bronchoconstrictive diseases such as asthma and chronic obstructive pulmonary disease (COPD). -
α1/α2 Adrenergic Receptor Antagonist
Phentolamine is a selective and orally active antagonist of α1 and α2 adrenergic receptors. This compound exhibits significant biological activity in modulating vascular tone and has been extensively utilized in research related to erectile dysfunction and adrenergic signaling. By inhibiting these receptors, Phentolamine promotes vasodilation and enhances blood flow, making it a valuable tool for studying cardiovascular and reproductive systems. -
β2-adrenergic receptor Agonist
Methoxyfenoterol is a selective β2-adrenergic receptor agonist known for its ability to stimulate intracellular cAMP accumulation. It exhibits significant anti-proliferative effects on tumor cells by inducing G1 cell cycle arrest, upregulating p27, and downregulating cyclin D1 and cyclin A levels, while also inhibiting Akt phosphorylation. Additionally, Methoxyfenoterol is capable of crossing the blood-brain barrier, demonstrating efficacy in inhibiting the growth of astrocytoma xenografts. This compound is primarily utilized in research related to astrocytoma and glioblastoma. -
Drug Impurity
Atenolol impurity 8 is a structural impurity associated with Atenolol, a selective beta-1 adrenergic receptor blocker. This compound is crucial for analyzing the purity of Atenolol formulations and evaluating potential impacts on drug efficacy and safety. It serves as an important reference standard in the pharmaceutical industry for quality control and compliance in drug development and analysis. -
Drug Impurity
Tamsulosin impurity 21 is a chemical impurity associated with the drug Tamsulosin, which primarily targets the α1-adrenergic receptors. This impurity may serve as a valuable reference standard in the analysis of Tamsulosin formulations. Its identification is crucial for assessing the purity and quality of pharmaceutical products in drug development and quality control. -
Adrenergic Prodrug
Dibutepinephrine is an orally active adrenergic prodrug that targets adrenergic receptors. It demonstrates significant efficacy in rapidly alleviating allergic symptoms, making it a valuable tool for studying severe allergic reactions. This compound is useful in research focused on the mechanisms of allergic responses and the development of therapeutic interventions. -
Adrenergic Receptor Antagonist
Tolazoline is an α-adrenergic receptor antagonist that plays a critical role in modulating vascular responses. It inhibits noradrenaline-induced cell contraction, affects vascular resistance, increases arterial pressure, and can reverse both bradycardia and tachypnea. This compound is valuable for studying erectile dysfunction, assessing α2-adrenergic receptor agonist-related poisoning, and investigating skin vascular diseases. -
alpha-adrenoceptor Antagonist
Acepromazine is a phenothiazine tranquilizer primarily acting as an alpha-adrenoceptor antagonist. It exhibits sedative and tranquilizing effects by blocking the adrenergic receptors, which can be valuable in veterinary medicine. Acepromazine is commonly utilized in studies involving sedation, anesthesia, and behavioral research, making it an important reagent for exploring neuropharmacological pathways. -
PN-1 Agonist
Serpinin is an agonist of the protease inhibitor Nexin-1 (PN-1), promoting its expression through the cAMP-PKA-Sp1 signaling pathway, which enhances granule biogenesis in endocrine cells. This compound is instrumental in studying the regulation of secretory functions and demonstrates selectivity for β-adrenergic receptors. By interacting with β1-adrenergic receptors, Serpinin activates the AC-cAMP-PKA pathway, crucial for regulating myocardial systolic and diastolic function. Additionally, pGlu-serpinin has been shown to upregulate Bcl2 mRNA transcription, contributing to its neuroprotective effects. -
ARα2c Inhibitor
BAY-2925976 is an α2C adrenergic receptor (ARα2C) inhibitor that selectively blocks receptor activity. This compound is primarily utilized in research related to obstructive sleep apnea (OSA), providing insights into its underlying mechanisms and potential therapeutic approaches. BAY-2925976 aids in elucidating the role of ARα2C in respiratory regulation and sleep disorders. -
β-AR Antagonist
Lubabegron fumarate is a selectiveβ-adrenergic receptor (β-AR) modulator, exhibiting antagonistic properties at both β1 and β2 receptor subtypes while acting as an agonist at the β3 subtype in bovine species. This compound effectively reduces ammonia (NH3) gas emissions from livestock and their waste, making it a valuable tool for improving environmental sustainability in agricultural practices. Lubabegron fumarate is primarily used in research applications focused on animal health and emissions management. -
5-HT/NE Reuptake Inhibitor
Dextromilnacipran is a selective serotonin and norepinephrine (5-HT/NE) reuptake inhibitor, derived from the enantiomeric form of milnacipran. This compound also functions as a human alpha-adrenergic receptor antagonist, exhibiting an IC50 value of 3.4 μM. Dextromilnacipran is primarily utilized in research applications targeting mood disorders and neuropharmacology, facilitating investigations into its psychiatric and physiological effects. -
Stable Isotope
Dextromilnacipran-d6 is a deuterium-labeled analog of Dextromilnacipran, a selective serotonin and norepinephrine (5-HT/NE) reuptake inhibitor. This compound also acts as a human alpha-adrenergic receptor antagonist, exhibiting an IC50 of 3.4 μM. Dextromilnacipran-d6 is a valuable tool for metabolic and pharmacokinetic studies, providing insights into the behavior and efficacy of 5-HT/NE reuptake inhibitors in various research contexts. -
Anti-adrenergic Agent, Anti-anginal Agent
L 8412 is a potent anti-adrenergic agent that primarily targets adrenergic receptors, leading to decreased heart rate and myocardial oxygen demand. It exhibits significant anti-anginal activity, making it valuable in cardiovascular research. This compound is utilized for studying the effects of adrenergic modulation on heart function and in the development of therapies for angina pectoris. -
Antihypertensive Agent
Alkaloids, Rauwolfia are derived from the root of Rauwolfia serpentina and act primarily as antihypertensive agents. These bioactive compounds have been shown to effectively lower blood pressure by targeting adrenergic receptors and modulating central nervous system activity. They are widely utilized in research to investigate hypertension and related cardiovascular conditions. -
Natural Extract
Yohimbe extract primarily targets adrenergic receptors due to its active component, yohimbine, an alkaloid. It is recognized for its biological activities, including the enhancement of sexual function, potential weight loss benefits, and promotion of blood circulation. This natural extract is widely utilized in pharmacological research and studies focused on cardiovascular health and metabolic regulation.
