Catalog No.
Product Name
Application
Product Information
Citations
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P2X1 Receptor Antagonist
NF449 octasodium is a potent antagonist of the P2X1 receptor, exhibiting IC50 values of 0.28 nM, 0.69 nM, and 120 nM for recombinant P2X1, recombinant P2X1 with 5, and P2X2+3 receptors, respectively. It selectively targets the Gsα subunit of G proteins, effectively inhibiting GTP[γS] binding to Gsα-s and reducing adenylyl cyclase activity. NF449 octasodium is useful in research focused on the regulation of P2X1 receptor-mediated signaling pathways and β-adrenergic receptor interactions. -
Potassium Channel Blocker
Besipirdine hydrochloride is a potassium channel blocker that exerts both cholinergic and adrenergic effects. Its cholinergic activity is characterized by stimulation of phosphatidylinositol turnover and a reduction in potassium currents, while its adrenergic activity promotes norepinephrine release through the inhibition of presynaptic α2-adrenergic receptors and the blocking of norepinephrine reuptake. This compound is applicable in research related to Alzheimer's disease, providing insights into potential therapeutic pathways. -
NR2B Antagonist
NMDA-IN-1 dihydrochloride is a selective antagonist of the NMDA NR2B receptor, exhibiting a Ki of 0.85 nM and an IC50 of 9.7 nM for NR2B-mediated Ca2+ influx. This compound effectively inhibits Glu/Gly-stimulated Ca2+ flux in Ltk- cells expressing hNR1a/NR2B, demonstrating specificity as it does not interact with NR2A, NR2C, NR2D, hERG channels, or α1-adrenergic receptors. NMDA-IN-1 dihydrochloride displays significant efficacy in mechanical hyperalgesia models in rats and is relevant for investigations into stroke, Parkinson's disease, and neuropathic pain. -
Stable Isotope
O-Desmethyl carvedilol-d5 is a deuterium-labeled derivative of O-Desmethylcarvedilol, a potent active metabolite of the non-selective β-adrenergic receptor antagonist Carvedilol. This compound exhibits inhibitory effects on store-overload-induced calcium release in HEK293 cells expressing the RyR2 R4496C mutation, with an IC50 of 7.62 μM. Additionally, O-Desmethyl carvedilol-d5 contributes to cardiovascular research by attenuating heart rate increases and stabilizing diastolic blood pressure in response to Isoproterenol in conscious rabbit models, demonstrating ED50 values of 32 and 5 μg/kg, respectively. -
NR4A1 Inhibitor
Glycerol kinase, microorganism functions as an NR4A1 inhibitor by directly binding to and inhibiting the transcription factor NR4A1, which plays a critical role in hepatic gluconeogenesis. This inhibition leads to reduced blood glucose levels and positively influences UCP1 expression through the β-adrenergic receptor-cAMP-CREB signaling pathway, promoting the browning of white adipose tissue and enhancing thermogenesis. Additionally, it modulates intracellular fatty acid composition and energy metabolism. Research using glycerol kinase in diabetic mouse models has demonstrated its ability to counteract NR4A1-induced hyperglycemia, indicating its potential applications in diabetes and obesity studies. -
Endogenous Metabolite
AZD-3199 is an ultra-long-acting beta2 adrenergic agonist primarily targeting the beta2 adrenergic receptor. It exhibits significant bronchodilator activity, making it a candidate for therapeutic use in asthma and chronic obstructive pulmonary disease (COPD) research. Its prolonged action facilitates investigations into novel treatment strategies for managing these respiratory conditions. -
5-HT/NE Reuptake Inhibitor
Dextromilnacipran is a selective serotonin and norepinephrine (5-HT/NE) reuptake inhibitor, derived from the enantiomeric form of milnacipran. This compound also functions as a human alpha-adrenergic receptor antagonist, exhibiting an IC50 value of 3.4 μM. Dextromilnacipran is primarily utilized in research applications targeting mood disorders and neuropharmacology, facilitating investigations into its psychiatric and physiological effects. -
Stable Isotope
Dextromilnacipran-d6 is a deuterium-labeled analog of Dextromilnacipran, a selective serotonin and norepinephrine (5-HT/NE) reuptake inhibitor. This compound also acts as a human alpha-adrenergic receptor antagonist, exhibiting an IC50 of 3.4 μM. Dextromilnacipran-d6 is a valuable tool for metabolic and pharmacokinetic studies, providing insights into the behavior and efficacy of 5-HT/NE reuptake inhibitors in various research contexts. -
PN-1 Agonist
Serpinin is an agonist of the protease inhibitor Nexin-1 (PN-1), promoting its expression through the cAMP-PKA-Sp1 signaling pathway, which enhances granule biogenesis in endocrine cells. This compound is instrumental in studying the regulation of secretory functions and demonstrates selectivity for β-adrenergic receptors. By interacting with β1-adrenergic receptors, Serpinin activates the AC-cAMP-PKA pathway, crucial for regulating myocardial systolic and diastolic function. Additionally, pGlu-serpinin has been shown to upregulate Bcl2 mRNA transcription, contributing to its neuroprotective effects. -
ARα2c Inhibitor
BAY-2925976 is an α2C adrenergic receptor (ARα2C) inhibitor that selectively blocks receptor activity. This compound is primarily utilized in research related to obstructive sleep apnea (OSA), providing insights into its underlying mechanisms and potential therapeutic approaches. BAY-2925976 aids in elucidating the role of ARα2C in respiratory regulation and sleep disorders. -
β-AR Antagonist
Lubabegron fumarate is a selectiveβ-adrenergic receptor (β-AR) modulator, exhibiting antagonistic properties at both β1 and β2 receptor subtypes while acting as an agonist at the β3 subtype in bovine species. This compound effectively reduces ammonia (NH3) gas emissions from livestock and their waste, making it a valuable tool for improving environmental sustainability in agricultural practices. Lubabegron fumarate is primarily used in research applications focused on animal health and emissions management. -
Drug Impurity
Mirabegron impurity 6 is a recognized impurity of the pharmaceutical compound Mirabegron, which primarily acts as a β3-adrenergic receptor agonist. It serves as an important reference standard for quality control in the synthesis and analysis of Mirabegron and is crucial in ensuring the purity and efficacy of the drug. This impurity can assist in research applications involving pharmacokinetics, safety assessments, and metabolic studies of β3-adrenergic modulators. -
Drug Impurity
Tamsulosin impurity 15 is a chemical impurity associated with the pharmaceutical compound Tamsulosin, which primarily targets alpha-1 adrenergic receptors. This impurity is relevant for quality control and characterization in the development and analysis of Tamsulosin formulations. Research applications include assessing the purity and safety profiles of Tamsulosin in pharmaceutical formulations. -
Drug Impurity
(S)-Tamsulosin hydrochloride is a chiral impurity associated with the pharmaceutical compound tamsulosin, primarily targeting alpha-1 adrenergic receptors. This reagent may serve a critical role in the analytical characterization and quality control of tamsulosin formulations. Its presence can impact the pharmacological profile and efficacy of the drug, making it an essential component for research and development in pharmaceutical sciences. -
Drug Impurity
Acebutolol impurity 7 is a secondary compound generated during the synthesis of Acebutolol, a selective beta-1 adrenergic receptor blocker. This reagent is primarily utilized in drug development and quality control to ensure the purity and safety of pharmaceutical formulations. Its characterization and analysis are essential for compliance with regulatory standards in chemical research and formulation studies. -
Drug Impurity
Dexmedetomidine impurity 2 is a chemical impurity related to Dexmedetomidine, a selective alpha-2 adrenergic receptor agonist. This impurity is significant in assessing the purity and quality of Dexmedetomidine formulations. It is utilized primarily in analytical chemistry and pharmaceutical development, particularly for the evaluation of drug substances and ensuring compliance with regulatory standards. -
Drug Impurity
Alfuzosin EP impurity 1 hydrochloride, also known as 2,3,4,5-Tetradehydro alfuzosin hydrochloride, is a recognized impurity of Alfuzosin hydrochloride. This compound is essential for evaluating the purity and stability of alfuzosin formulations in pharmaceutical development. Researchers may utilize this impurity in studies assessing drug quality, pharmacokinetics, and mechanism of action related to alpha-1 adrenergic receptor antagonism. -
Adrenaline Impurity
Methoxy adrenaline hydrochloride is a synthetic analog of adrenaline, serving as a known impurity in adrenaline formulations. Its presence is critical for quality control in pharmaceutical research, allowing for the assessment of purity and stability in adrenaline products. This compound can also be utilized in various biological studies to investigate adrenergic receptor interactions and signaling pathways. -
Drug Impurity
Metoprolol Impurity 13 is a chemical impurity associated with Metoprolol, a selective beta-1 adrenergic receptor antagonist. This impurity can be utilized for analytical purposes in drug development, including stability studies and quality control assessments. Researchers can employ this compound to ensure the purity and compliance of Metoprolol formulations in pharmaceutical applications. -
Drug Intermediate Control
(Rac)-7-Methoxy propranolol is a key synthetic intermediate that plays a critical role in the production of pharmaceuticals. This compound is utilized in drug formulation and development, particularly in studies related to beta-adrenergic receptor antagonism, which is important for cardiovascular research. Its chemical structure facilitates various synthetic pathways in the creation of effective therapeutics. -
Drug Impurity
Tamsulosin impurity 5 is a known impurity associated with Tamsulosin, a selective alpha-1 adrenergic receptor antagonist primarily used to treat benign prostatic hyperplasia. This specific impurity plays a crucial role in quality control and analytical studies aimed at evaluating the purity and stability of Tamsulosin formulations. It is essential for researchers focusing on the pharmacokinetics and safety profiles of the drug. -
Drug Impurity
Mirabegron impurity 12 is a known impurity associated with the pharmaceutical compound Mirabegron, which primarily acts as a β3-adrenergic receptor agonist. This impurity may be important for analytical characterization and quality control in pharmaceutical research and development. Its detection and quantification can aid in understanding the safety and efficacy profiles of Mirabegron formulations. -
Drug Impurity
Brimonidine impurity 3 is a chemical impurity associated with the drug Brimonidine, primarily targeting adrenergic receptors. This compound is relevant for quality control in pharmaceutical formulations and can be utilized to study the stability and degradation pathways of Brimonidine. Its characterization contributes to the development of safer and more effective drug products. -
Drug Impurity
Carvedilol impurity 13 is a known impurity of the beta-blocker carvedilol, which primarily targets beta-adrenergic receptors. This compound is utilized in pharmaceutical research to assess the purity and stability of carvedilol formulations. Its characterization is essential for ensuring compliance with regulatory standards and improving drug quality. -
α1 Adrenergic Receptor Agonist
Phenylephrine hydrochloride is an α1 adrenergic receptor agonist primarily used as a sympathomimetic agent. It induces vasoconstriction and increases perfusion pressure, making it valuable in clinical settings for managing hypotension and as a decongestant. Researchers utilize Phenylephrine hydrochloride to study cardiovascular responses and the pharmacological effects of adrenergic activation in various biological systems. -
Drug Impurity
Mirabegron impurity 10 is a known impurity associated with the pharmacological agent Mirabegron, a selective beta-3 adrenergic receptor agonist. It is crucial for studies focused on drug purity and stability, as well as for understanding the synthesis and degradation pathways of Mirabegron. This impurity serves as a reference standard for analytical methods and quality control processes in pharmaceutical development and research applications. -
Drug Impurity
Salbutamol impurity 7 is a known impurity of the bronchodilator Salbutamol, which primarily targets beta-2 adrenergic receptors. This compound is important for analytical research and quality control in pharmaceutical development to ensure the purity and safety of Salbutamol formulations. Its presence can influence pharmacokinetics and therapeutic efficacy, making it relevant for studies focused on drug metabolism and impurities. -
Derivative of Clonidine
Acetylclonidine is a derivative of Clonidine that targets imidazoline and adrenergic receptors. It exhibits biological activity in reducing intraocular pressure, making it a valuable reagent for research into ocular antihypertensive agents for the treatment of glaucoma. Its unique profile may provide insights into novel therapeutic approaches in ocular health. -
Desfluorinated Nebivolol Isomer
Desfluoro nebivolol is a desfluorinated isomer of the antihypertensive agent nebivolol, primarily acting as a beta-adrenergic receptor blocker. This compound exhibits pharmacological activity related to cardiovascular regulation, making it relevant for research in hypertension and heart failure therapies. Its unique chemical structure allows for exploration of β-blockade mechanisms and potential therapeutic benefits, providing valuable insights for the development of cardiovascular treatments. -
Drug Derivative
Cetamolol is a drug derivative that primarily targets beta-adrenergic receptors. It exhibits significant cardioprotective effects and is utilized in research focusing on cardiovascular pharmacology. Its ability to modulate heart rate and blood pressure makes it valuable for investigating hypertension and related cardiovascular disorders. -
Drug Derivative
TA-993 is a drug derivative that enhances limb blood flow primarily through the modulation of the sympathetic nervous system, bypassing adrenergic receptors. This compound demonstrates a distinctive mechanism of action, potentially influencing heart rate through alternative pathways. TA-993 is valuable for research applications focused on understanding vascular dynamics and autonomic control in various physiological and pathological states. -
Vasoconstrictor Agent
Nordefrin, a derivative of norepinephrine, functions primarily as a vasoconstrictor agent. It exerts its biological activity by stimulating adrenergic receptors, leading to increased vascular resistance and elevated blood pressure. This compound is commonly utilized in research investigations focused on cardiovascular physiology and pharmacology, particularly those exploring blood pressure regulation and vascular function. -
Guanfacine Derivative
Etiguanfacine is a derivative of Guanfacine that primarily targets alpha-2 adrenergic receptors. It exhibits potential for reducing gastrointestinal side effects commonly associated with Guanfacine, making it a valuable tool for research into improved therapeutic profiles. This compound can be utilized in studies involving hypertension and attention-deficit hyperactivity disorder (ADHD), as well as in evaluating receptor-mediated mechanisms in neuropharmacology. -
Drug Derivative
Fepradinol is a drug derivative that primarily acts as a selective modulator of adrenergic receptors. This compound exhibits significant biological activity in influencing cardiovascular responses and can be utilized in research focused on cardiovascular pharmacology. Its modulatory effects make it valuable for investigating the therapeutic potential in treating various cardiovascular disorders. -
Drug Derivative
Methoserpidine is a drug derivative that primarily functions as an antagonist of the alpha-adrenergic receptor. This compound exhibits significant biological activity in modulating cardiovascular responses and neurotransmitter release, making it useful for research in hypertension and other cardiovascular disorders. Its properties enable exploration of adrenergic signaling pathways and may provide insights into potential therapeutic strategies. -
Dexoxadrol Enantiomer
Levoxadrol is the active enantiomer of dexoxadrol, primarily targeting adrenergic receptors. This compound exhibits potent agonistic activity, making it valuable for research applications in cardiovascular and neuropharmacology studies. Its distinct biological properties facilitate investigations into adrenergic signaling pathways and their role in various physiological and pathological conditions. -
Nasal Vasoconstrictor
Tymazoline hydrochloride is an imidazoline derivative known for its nasal vasoconstrictor properties. It acts primarily on alpha-adrenergic receptors, leading to the reduction of nasal mucosal edema. This compound is valuable in research applications related to rhinitis and other conditions involving nasal congestion. -
Pressor/Sympathomimetic Agent
Gepefrine is an orally active sympathomimetic agent with pressor properties. It primarily targets adrenergic receptors, enhancing vascular response and improving arterial pressure regulation. Gepefrine is utilized in research to study its effects on orthostatic dysregulation and cardiovascular dynamics. -
Propranolol Analogue
KP-19 is a Propranolol analogue that targets β-adrenergic receptors, influencing cardiac function and stress response. This compound exhibits potential biological activity in modulating cardiovascular mechanisms and offers insights into the treatment of cardiovascular diseases. Its application in research may contribute to understanding therapeutic strategies for managing heart-related conditions. -
Intermediate
4-Propionamidophenol is an important intermediate in the synthesis of alkanolamine derivatives, primarily targeting β-adrenergic receptors. This compound exhibits significant β-adrenergic blocking activity, making it useful for research into cardiovascular conditions, including heart disease and hypertension. Its utility in synthesizing related compounds enhances its potential for various pharmacological studies. -
Drug Derivative
Indanazoline is a drug derivative that acts primarily as a selective vasoconstrictor. It exhibits significant vasoconstrictive activity through its interactions with adrenergic receptors, making it valuable in cardiovascular research. This compound can be utilized in studies focusing on blood pressure regulation and vascular dynamics, contributing to the understanding of hypertensive conditions and related pharmacological treatments. -
Biochemical Assay Reagent Control
Clenhexerol is a selective beta-adrenergic agonist that primarily targets beta-2 adrenergic receptors. This compound exhibits biological activity by stimulating smooth muscle relaxation and inducing bronchodilation. It is commonly used as a biochemical assay reagent control in research focused on respiratory diseases, pharmacological studies, and the exploration of adrenergic signaling pathways. -
Stable Isotope
3-O-Methyl Colterol-d9 is a deuterium-labeled analog of 3-O-Methyl Colterol. This stable isotope is utilized in analytical studies to track metabolic pathways and quantify interactions in biological systems. Its primary applications include pharmacokinetic studies and the investigation of drug metabolism, enhancing the understanding of biological processes involving beta-adrenergic receptors. -
Stable Isotope
Atenolol-d6 is a deuterium-labeled variant of the cardioselective β1-adrenergic receptor blocker, Atenolol. It exhibits a Ki of 697 nM at the β1-adrenoceptor in guinea pig left ventricle membranes. This stable isotope is instrumental in pharmacokinetic studies and research focused on hypertension and angina pectoris, allowing for improved metabolic tracing and analytical characterization in various biological assays. -
Stable Isotope
Labetalol hydrochloride-d5 is a deuterium-labeled form of Labetalol hydrochloride, specifically designed as a stable isotope for research applications. This compound functions as a selective α1-adrenergic and non-selective β-adrenergic receptor antagonist, primarily utilized for its antihypertensive properties. It is suitable for studying cardiovascular conditions, including hypertension, especially in contexts such as pregnancy where blood pressure regulation is critical. The stable isotope labeling facilitates advanced pharmacokinetic and metabolic studies. -
Stable Isotope
1-Oxo Colterol-d9 is a deuterium-labeled analog of 2-(Tert-butylamino)-1-(3,4-dihydroxyphenyl)ethan-1-one, serving as a stable isotope standard. This compound is valuable for quantitative mass spectrometry applications in biochemical research, particularly in studies involving adrenergic receptor signaling and pharmacokinetics. Its incorporation of deuterium enables precise tracking and analysis of metabolic pathways, enhancing the understanding of drug metabolism and activity. -
Stable Isotope
5'-Hydroxyphenyl carvedilol-d5 is a stable isotope-labeled analogue of carvedilol, targeting beta-adrenergic receptors. This deuterated compound is useful in pharmacokinetic studies, enabling the tracing of metabolic pathways and the assessment of drug disposition in various biological systems. Its structural modifications enhance the sensitivity and accuracy of analytical methods, making it an essential reagent for research applications in cardiovascular pharmacology and drug development. -
Adrenergic Receptor Antagonist
Yohimbine-d3 is a deuterated derivative of Yohimbine, functioning as an adrenergic receptor antagonist. This compound is utilized in research to study the modulation of adrenergic signaling pathways, specifically the alpha-2 adrenergic receptors. Its applications include investigations into the effects of adrenergic blockade on physiological processes and the potential therapeutic roles in conditions such as depression and sexual dysfunction. -
Stable Isotope
Dexmedetomidine-d4 L-tartrate (-d4-major) is a deuterium-labeled derivative of Dexmedetomidine L-tartrate, serving as a stable isotope for research applications. This compound is primarily utilized in pharmacokinetic studies and metabolic labeling, enabling accurate tracking of drug disposition and action mechanisms. It supports investigations into alpha-2 adrenergic receptor modulation and sedation research, providing insights into the pharmacological properties of its parent compound. -
Stable Isotope
(R)-(+)-Celiprolol-d9 hydrochloride is a deuterium-labeled analogue of the racemic beta-blocker Celiprolol, primarily targeting beta-adrenergic receptors. This stable isotope derivative facilitates precise pharmacokinetic studies and isotopic labeling experiments in chemical research. Its unique properties make it suitable for applications in metabolomics, drug metabolism, and tracer studies to elucidate the pharmacodynamics of beta-blockers.
