Neuropeptide S Receptor

ML154 is a selective non-peptide antagonist of the neuropeptide S receptor (NPSR), demonstrating efficient brain penetration. This compound effectively inhibits NPS-induced cellular responses, including calcium influx, cAMP accumulation, and ERK phosphorylation, with IC50 values of 36.5 nM, 22.1 nM, and 9.3 nM, respectively. ML154 is a valuable tool for investigating the role of NPSR in various physiological and pathological processes.

R06039-691 is an agonist of the neuropeptide S receptor (NPSR), exhibiting an EC50 of 93 nM. This compound is involved in the modulation of several biological functions, including arousal, stress and anxiety responses, memory processes, and food intake, through the activation of NPSR. Its ability to influence these physiological pathways makes R06039-691 a valuable tool for research in neurobiology and potential therapeutic applications in anxiety and related disorders.

R06039-641 is a potent neuropeptide S receptor (NPSR) agonist with an EC50 value of 169 nM. By activating NPSR, R06039-641 modulates various physiological processes, including arousal, stress and anxiety responses, memory formation, and appetite regulation. This compound is valuable for research focused on neurobiology and behavioral sciences.

R06039-693 is a neuropeptide S receptor (NPSR) agonist, exhibiting an EC50 value of 169 nM. By activating NPSR, R06039-693 plays a pivotal role in modulating several biological functions, including arousal, stress and anxiety responses, memory processes, and food intake regulation. This compound is valuable for researchers investigating neuropeptide signaling pathways and their implications in neurobiology and behavioral science.

R06039-696 is a selective agonist of the neuropeptide S receptor (NPSR) with an EC50 of 91 nM. This compound plays a significant role in modulating various biological functions, including arousal, stress and anxiety responses, memory processes, and appetite regulation. R06039-696 is valuable for research applications focused on neurobiology and stress-related disorders.

NPSR1 modulator-1 is a selective modulator of the neuropeptide S receptor 1 (NPSR1), influencing its signaling pathways. This compound exhibits potential biological activity in regulating stress response and anxiety-related behaviors. It is primarily utilized in research focusing on neuropharmacology and the development of therapeutic strategies for anxiety disorders.