ML154 is a selective non-peptide antagonist of the neuropeptide S receptor (NPSR), demonstrating efficient brain penetration. This compound effectively inhibits NPS-induced cellular responses, including calcium influx, cAMP accumulation, and ERK phosphorylation, with IC50 values of 36.5 nM, 22.1 nM, and 9.3 nM, respectively. ML154 is a valuable tool for investigating the role of NPSR in various physiological and pathological processes.
ML154 is a selective non-peptide antagonist of the neuropeptide S receptor (NPSR), demonstrating efficient brain penetration. This compound effectively inhibits NPS-induced cellular responses, including calcium influx, cAMP accumulation, and ERK phosphorylation, with IC50 values of 36.5 nM, 22.1 nM, and 9.3 nM, respectively. ML154 is a valuable tool for investigating the role of NPSR in various physiological and pathological processes.
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