Oxytocin Receptor

(E/Z)-OT-R antagonist 1 is a mixture of E and Z isomers that functions as a selective, non-peptide antagonist of the oxytocin receptor (OT-R). This compound effectively inhibits oxytocin-induced intracellular calcium activation, exhibiting an IC50 value of 8 nM. Its potent antagonistic activity makes it a valuable tool for investigating the role of oxytocin signaling in various biological processes and pathological conditions. Researchers can utilize this reagent in studies related to neurobiology, reproductive health, and stress response mechanisms.

L-364918 is a selective antagonist of oxytocin and arginine vasopressin, exhibiting Ki values of 30 nM for oxytocin, 1300 nM for AVP-V1, and 2400 nM for AVP-V2. This compound may be beneficial for research focused on preterm labor and conditions related to water balance dysregulation. Its pharmacological profile supports investigations into the role of these neuropeptides in various physiological and pathological processes.

OT-R Agonist 1 TFA is a potent oxytocin receptor agonist with an EC50 value of 0.39 nM, making it an excellent tool for investigating oxytocin signaling pathways. Additionally, this compound exhibits V1A antagonist activity with an EC50 of 2432 nM. It is primarily utilized in research related to central nervous system disorders, providing insights into neurobiology and potential therapeutic approaches.

L-365209 is an oxytocin antagonist that selectively inhibits the binding of oxytocin to its receptors. Its primary mechanism involves blocking the physiological effects mediated by oxytocin, which is critical in processes such as social behavior, reproduction, and stress responses. This compound is valuable for research applications investigating the role of oxytocin in various physiological and pathological conditions.

OXTR modulator-1 is an oxytocin receptor (OXTR) modulator that selectively influences OXTR activity. This compound exhibits potential biological activity in enhancing social behavior and emotional processing, making it a valuable tool for research into neuropsychiatric disorders and social cognition. Its applications extend to studies investigating the physiological and therapeutic roles of oxytocin in various animal models.

OXTR modulator-2 is a selective modulator of the oxytocin receptor (OXTR), influencing pathways associated with social behavior and emotional responses. This compound enhances OXTR activity, making it instrumental in research on neuropsychiatric disorders, stress resilience, and social cognition. Its application extends to investigating the role of oxytocin in various biological processes, enabling insights into therapeutic strategies targeting mood and anxiety disorders.

Oxytocin (α-Hypophamine) acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma.

Retosiban (GSK-221,149-A) is an oral drug which acts as a selective, sub-nanomolar (Ki = 0.65 nM) oxytocin receptor antagonist with >1400-fold selectivity[3] over the related vasopressin receptors

PF-3274167 is a high-affinity nonpeptide oxytocin receptor (OTR) antagonist, with Ki of 9.5 nM.

Oxytocin (α-Hypophamine) is a mammalian neurohypophysial hormone; its actions are mediated by specific, high-affinity oxytocin receptors; ligand of oxytocin receptor.

Carbetocin (Lonactene; Duratocin) is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth; an agonist at peripheral oxytocin receptors.

OT-R antagonist 2 is a nonpeptide low molecular weight OT-R antagonist. OT-R antagonist 2 inhibitis IP3-Synthesis, rat OT-R (IC50 = 0.33 μM).

OT-R antagonist 1 is a new potent and selective nonpeptide low molecular weight OT-R antagonist.

L-371,257 is an orally bioavailable, non-blood-brain barrier penetrant, selective and competitive antagonist of oxytocin receptor (pA2=8.4) with high affinity at both the oxytocin receptor (Ki=19 nM) and vasopressin V1a receptor (Ki=3.7 nM).

L-368,899 hydrochloride is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC50s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively, used as a tocolytic agent.

OT antagonist 1 (Compound 4) is a potent, selective Oxytocin antagonist with a Ki of 50 nM.

OT antagonist 3 is an oxytocin (OT) antagonist extracted from patent WO2007017752A1.

SHR1653 is a highly potent, selective and brain penetrated oxytocin receptor (OTR) antagonist, with an IC50 of 15 nM for hOTR.

Epelsiban (GSK 557296) is a potent, selective and orally bioavailable oxytocin receptor antagonist, with a pKi of 9.9 for human oxytocin receptor.