A-485

Catalog No.: A16830

p300/CBP inhibitor

A-485

A-485 Chemical Structure

CAS NO. 1889279-16-6

A-485 is a potent and selective HAT inhibitor of p300/CBP in vitro with an IC50 of 10 nM in a p300 TR-FRET assay and 3 nM in a CBP TR-FRET assay with selectivity > 1000-fold over closely related HATs.

Availability: In stock

Package Price Qty
2 mg
$120.00
5 mg
$205.00
10 mg
$360.00
50 mg
$1,400.00
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Biological Activity

A-485 is a potent and selective HAT inhibitor of p300/CBP in vitro with an IC50 of 10 nM in a p300 TR-FRET assay and 3 nM in a CBP TR-FRET assay with selectivity > 1000-fold over closely related HATs.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.64 mL 93.2 mL 186.4 mL
0.5 mM 3.73 mL 18.64 mL 37.28 mL
1 mM 1.86 mL 9.32 mL 18.64 mL
5 mM 0.37 mL 1.86 mL 3.73 mL

*The above data is based on the productmolecular weight 536.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16830
Actions Inhibitor
M. Wt 536.48
Formula C25H24F4N4O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1889279-16-6
Synonyms A 485, A485
SMILES O=C(N1CC(N([[email protected]](C(F)(F)F)C)CC2=CC=C(F)C=C2)=O)[[email protected]@]3(OC1=O)CCC4=CC(NC(NC)=O)=CC=C43

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