Histone Acetyltransferases

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  1. p300 inhibitor

    Histone Acetyltransferase Inhibitor II is a potent and cell permeable p300 inhibitor, with an IC50 of 5μM; Histone Acetyltransferase Inhibitor II can be used in cancer research.
  2. GSK 4027 is a chemical probe for the PCAF/GCN5 bromodomain with an pIC50 of 7.4??0.11 for PCAF in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.
  3. CBP/P300 benzoxazepine bromodomain inhibitor

    TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor with Kd values of 134 nM and 5.02 μM for CBP and BRD4.
  4. HAT inhibitor

    Garcinol is a polyisoprenylated benzophenone derivative isolated from Garcinia indica. It is a potent inhibitor of histone acetyltransferases (HATs) p300 (IC50=7μM) and PCAF (IC50=5μM) both in vitro and in vivo.
  5. p300/CBP inhibitor

    C646 is a selective p300/CREB-binding protein (CBP) inhibitor (Ki = 400 nM).
  6. CBP/p300 bromodomain inhibitor

    I-CBP112 is a highly potent and selective p300/CBP bromodomain inhibitor (IC50 ~0.14-0.17 uM for CBP and ~0.625 uM for p300).
  7. CBP/p300 bromodomain inhibitor

    SGC-CBP30 is a potent and selective inhibitor of CREBBP (CBP) and EP300; which are general transcriptional co-activators.
  8. KAT5 (Tip60) HAT inhibitor

    NU9056 is an selective KAT5 (Tip60) HAT inhibitor. IC50 values are < 2, 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively. Inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Decreases proliferation of LNCaP cells; induces apoptosis via caspase activation.
  9. NAT10 inhibitor

    Remodelin Hydrobromide is a potent acetyl-transferase NAT10 inhibitor.
  10. KAT5 (Tip60), p300/PCAF inhibitor

    Anacardic Acid is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases.
  11. KAT5 (Tip60) HAT inhibitor

    MG149 is a potent histone acetyltransferase inhibitor with IC50 of 74 uM and 47 uM for Tip60 and MOF.
  12. CBP/beta-catenin antagonist

    PRI-724 is the second-generation, potent and specific inhibitor of CBP/β-Catenin complex, and a modulator of the β-Catenin dependent canonical Wnt signaling pathway in cancer stem cells.

  13. CBP/p300 inhibitor

    EML 425 is a reversible and non-competitive CBP/p300 inhibitor that is cell permeable (IC50 values are 1.1 and 2.9 uM, respectively).
  14. CBP/EP300 bromodomain inhibitor

    CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
  15. lysine acetyltransferase KAT6A inhibitor

    WM-1119 is a highly potent, selective inhibitor of lysine acetyltransferase KAT6A with IC50 of 0.25 μM. It is 1,100-fold and 250-fold more active against KAT6A than against KAT5 or KAT7, respectively.
  16. p300/CBP inhibitor

    A-485 is a potent and selective HAT inhibitor of p300/CBP in vitro with an IC50 of 10 nM in a p300 TR-FRET assay and 3 nM in a CBP TR-FRET assay with selectivity > 1000-fold over closely related HATs.
  17. CBP/beta-catenin modulator

    E-7386 is an orally active CBP/beta-catenin modulator.
  18. FACT inhibitor

    CBL0137 is a FACT inhibitor that functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death.
  19. p300/CBP histone acetyltransferase inhibitor

    P300/CBP-IN-3, a p300/CBP histone acetyltransferase inhibitor.
  20. p300 HAT activator

    CTPB is an activator of p300 HAT (histone acetyltransferase) without PCAF (p300/CBP-associated factor) HAT activities.
  21. CBP bromodomain inhibitor

    GNE-207 is a novel, potent, and orally bioavailable inhibitor of the bromodomain of CBP. GNE-207 has excellent CBP potency (CBP IC50?=?1?nM, MYC EC50?=?18?nM), and it exhibits a good pharmacokinetic profile.
  22. CBP inhibitor

    GNE-781 is a highly potent and selective CBP inhibitor with an IC50 of 0.94 nM in TR-FRET assay. GNE-781 also inhibits BRET and BRD4(1) with IC50s of 6.2 nM and 5100 nM, respectively.
  23. MOZ inhibitor

    WM-8014 is an inhibitor of MOZ, a member of histone acetyltransferases, with an IC50 of 55 nM.
  24. protein MOZ inhibitor

    MOZ-IN-2 is an inhibitor of protein MOZ, a member of histone acetyltransferases, with an IC50 of 125 μM.
  25. p300/CBP bromodomain inhibitor

    CBP-IN-1 is a potent p300/CBP bromodomain inhibitor.
  26. CBP inhibitor

    GNE-049 is a highly potent and selective CBP inhibitor with an IC50 of 1.1 nM in TR-FRET assay. GNE-049 also inhibits BRET and BRD4(1) with IC50s of 12 nM and 4200 nM, respectively.
  27. KAT3B inhibitor

    L002 is a novel potent, specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 uM.
  28. histone acetyltransferase activator

    YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease.
  29. BBD(NSC240867; Benzylamino-NBD) is a biochemical reagent/chromogenic reagent.
  30. acetyl-transferase protein NAT10 inhibitor

    Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.
  31. CBP/p300 histone acetyltransferase activator

    TTK21 is a CBP/p300 histone acetyltransferase activator.
  32. HAT inhibitor

    CPTH2 is a potent histone acetyltransferase (HAT) inhibitor.
  33. HBO1 inhibitor

    WM 3835 is a lysine acetyltransferase HBO1 (KAT7) inhibitor.

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