A-836339 is a selective agonist of the CB2 receptor, demonstrating Ki values of 0.4 nM and 0.8 nM for human and rat CB2 receptors, respectively. It exhibits significant analgesic, anti-inflammatory, gastric protective, and antioxidant activities. Activation of CB2 receptors in the dorsal root ganglia and spinal cord mediates its antinociceptive properties. Additionally, A-836339 reduces pro-inflammatory cytokines like TNF-α and IL-1β while enhancing the activity of antioxidant enzymes such as catalase and superoxide dismutase. This compound is valuable for research into inflammatory pain, neuropathic pain, gastric ulcers, and cerebral ischemia.
A-836339 is a selective agonist of the CB2 receptor, demonstrating Ki values of 0.4 nM and 0.8 nM for human and rat CB2 receptors, respectively. It exhibits significant analgesic, anti-inflammatory, gastric protective, and antioxidant activities. Activation of CB2 receptors in the dorsal root ganglia and spinal cord mediates its antinociceptive properties. Additionally, A-836339 reduces pro-inflammatory cytokines like TNF-α and IL-1β while enhancing the activity of antioxidant enzymes such as catalase and superoxide dismutase. This compound is valuable for research into inflammatory pain, neuropathic pain, gastric ulcers, and cerebral ischemia.
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