A1874

Catalog No.: A18735

BRD4-degrading PROTAC

A1874

A1874 Chemical Structure

CAS NO. 2064292-12-0

A1874 is a nutlin-based and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation.

Availability: In stock

Package Price Qty
1 mg
$180.00
5 mg
$620.00
10 mg
$880.00
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Biological Activity

A1874 is a nutlin-based and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 8.52 mL 42.6 mL 85.21 mL
0.5 mM 1.7 mL 8.52 mL 17.04 mL
1 mM 0.85 mL 4.26 mL 8.52 mL
5 mM 0.17 mL 0.85 mL 1.7 mL

*The above data is based on the productmolecular weight 1173.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18735
M. Wt 1173.6
Formula C58H62Cl3F2N9O7S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 2064292-12-0
Synonyms A1874, A-1874
SMILES O=C([[email protected]@H]1N[[email protected]@H](CC(C)(C)C)[[email protected]](C#N)(C2=CC=C(Cl)C=C2F)[[email protected]]1C3=CC=CC(Cl)=C3F)NC4=CC=C(C(NCCOCCOCCOCCNC(C[[email protected]]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5)=O)=O)C=C4

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