A1899 is a selective blocker of the two-pore potassium channel TASK-1, exhibiting IC50 values of 35.1 nM in oocytes and 7 nM in CHO cells. Additionally, A1899 functions as an IKur blocker, making it a valuable tool in the study of cardiac electrophysiology and related cardiovascular diseases. Its potency and specificity allow for detailed investigation into the physiological roles of potassium channels in cellular and cardiovascular research.
A1899 is a selective blocker of the two-pore potassium channel TASK-1, exhibiting IC50 values of 35.1 nM in oocytes and 7 nM in CHO cells. Additionally, A1899 functions as an IKur blocker, making it a valuable tool in the study of cardiac electrophysiology and related cardiovascular diseases. Its potency and specificity allow for detailed investigation into the physiological roles of potassium channels in cellular and cardiovascular research.
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