α4 integrin receptor antagonist 3 is a potent orally active antagonist of the α4 integrin receptor. It effectively inhibits the adhesion of K562 cells through the α4β1/VCAM-1 and α4β7/MAdCAM-1 interactions, demonstrating IC50 values of 130 nM and 2 nM, respectively. This compound is suitable for research applications involving inflammatory disorders and may be particularly useful in the study of dextran sulfate sodium (DSS) colitis models.
α4 integrin receptor antagonist 3 is a potent orally active antagonist of the α4 integrin receptor. It effectively inhibits the adhesion of K562 cells through the α4β1/VCAM-1 and α4β7/MAdCAM-1 interactions, demonstrating IC50 values of 130 nM and 2 nM, respectively. This compound is suitable for research applications involving inflammatory disorders and may be particularly useful in the study of dextran sulfate sodium (DSS) colitis models.
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