ABC294640

Catalog No.: A12614

SphK2 inhibitor

ABC294640

ABC294640 Chemical Structure

CAS NO. 915385-81-8

ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity.

Availability: In stock

Package Price Qty
5 mg
$80.00
10 mg
$150.00
25 mg
$270.00
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Biological Activity

ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity.
Targets
SphK2
60 μM
In vitro (25°C) DMSO Warmed: 75 mg/mL (196.89 mM)
Water Insoluble
Ethanol 28 mg/mL (73.5 mM)
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.3 mL 131.52 mL 263.04 mL
0.5 mM 5.26 mL 26.3 mL 52.61 mL
1 mM 2.63 mL 13.15 mL 26.3 mL
5 mM 0.53 mL 2.63 mL 5.26 mL

*The above data is based on the productmolecular weight 380.16554. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12614
Actions Inhibitor
CAS No. 915385-81-8
Formula C23H25ClN2O
M. Wt 380.16554
Solubility DMSO
Purity >98%
Synonyms ABC-294640, ABC 294640
SMILES C1[[email protected]]2CC3(CC1CC(C2)(C3)C(=O)NCC4=CC=NC=C4)C5=CC=C(C=C5)Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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