• Sign In
  • FAQ
  • Create an Account
Currency
USD
Toggle Nav
My Cart
Search
Menu
Account
Settings
Currency
USD

S1P Receptor

23 Items

per page
Set Descending Direction
Catalog No.
Product Name
Application
Product Information
Product Citation
  1. A10408
    FTY720 (Fingolimod)

    S1P Receptor antagonist

    FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine.
    Quick View
  2. A12265
    TY-52156

    S1P3 receptor antagonist

    TY-52156 is a potent and selective S1P3 receptor antagonist with a Ki value of 110 nM.
    Quick View
  3. A12614
    Opaganib (ABC294640)

    SphK2 inhibitor

    ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity.
    Quick View
  4. A12906
    BAF312 (Siponimod)

    S1PR1/S1PR5 inhibitor

    BAF312 is a next-generation potent sphingosine 1-phosphate (S1P) receptor agonist, selective for S1P1 and S1P5.
    Quick View
  5. A13307
    Ponesimod

    S1P1 receptor modulator

    Ponesimod is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM.
    Quick View
  6. A13308
    KRP-203

    S1PR1 inhibitor

    KRP-203 is a selective Sphingosine-1-phosphate receptor agonist. It shows to reduce peripheral lymphocyte infiltration and to prolong survival in rat transplant models.
    Quick View
  7. A13637
    CYM 5442 HCl

    EDG-1 (S1P1) agonist

    CYM 5442 HCl is a potent and selective EDG-1 (S1P1) agonist in vitro (EC50 = 1.35 nM).
    Quick View
  8. A15819
    RPC1063 (Ozanimod)

    S1PR1 modulators

    RPC1063 is a selective sphingosine 1 phosphate receptor modulators and methods which may be useful in the treatment of S1P1-?associated diseases.
    Quick View
  9. A15833
    NS13001

    SK2 modulator

    NS13001 is a selective SK2/3 modulator that acts as a potential therapeutic agent for treatment of SCA2 and possibly other cerebellar ataxias.
    Quick View
  10. A17798
    Fingolimod

    S1P antagonist

    Fingolimod is a sphingosine 1-phosphate (S1P) antagonist with IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant.
    Quick View
  11. A18432
    ASP1126

    S1P agonist

    ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively.
    Quick View
  12. A19575
    ASP-4058

    S1P1 and S1P5 agonist

    ASP-4058 is a next-generation, selective and oral bioactive agonist for Sphingosine 1-Phosphate receptors 1 and 5 (S1P1 and S1P5), ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile.
    Quick View
  13. A20102
    VPC 23019

    S1P antagonist

    VPC 23019, an aryl amide-containing Sphingosine 1-phosphate (S1P) analog, is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively) and an agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively).
    Quick View
  14. A20461
    S1p receptor agonist 1

    S1P receptor agonist

    S1p receptor agonist 1 is an S1P receptor agonist extracted from patent WO 2015039587 A1, compound example 2.
    Quick View
  15. A20489
    CYM-5541

    S1P3 receptor agonist

    CYM-5541 (ML249) is an selective and allosteric S1P3 receptor agonist with an EC50 between 72 and 132 nM.
    Quick View
  16. A20580
    W146

    S1PR1 antagonist

    W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.
    Quick View
  17. A20752
    GSK2018682

    S1P1/S1P5 receptor agonist

    GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4. GSK2018682 is used in the research of multiple sclerosis.
    Quick View
  18. A20913
    Cenerimod

    S1P1 agonist

    Cenerimod (ACT-334441) is a potent and orally available sphingosine 1-phosphate 1 receptor (S1P1) agonist extracted from patent WO 2016184939 A1 and WO 2011007324 A1, example 1, with an EC50 of 2.7 nM.
    Quick View
  19. A21324
    FTY720 (S)-Phosphate

    S1PR1 agonist

    FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.
    Quick View
  20. A21386
    PF429242 dihydrochloride

    S1P inhibitor

    PF429242 dihydrochloride is a reversible and competitive S1P inhibitor with an IC50 of 175 nM.
    Quick View
  21. A22072
    CYM50308

    sphingosine-1-phosphate receptor 4 (S1P4-R) agonist

    CYM50308 (ML248) is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with an EC50 of 56 nM.
    Quick View
  22. A22099
    NIBR-0213

    S1P(1) antagonist

    NIBR-0213 is a potent and selective antagonist of S1P(1) with efficacy in experimental autoimmune encephalomyelitis.
    Quick View
  23. A22583
    JTE-013

    S1P2 antagonist

    JTE-013 is a potent and specific S1P2 (Sphingosine-1-Phosphate 2; EDG-5) antagonist. JTE-013 inhibits the specific binding of radiolabeled S1P to human and rat S1P2 with IC50s of 17 nM and 22 nM, respectively.
    Quick View

23 Items

per page
Set Descending Direction