Abiraterone-d4, a deuterium-labeled derivative of Abiraterone, functions as a potent and irreversible inhibitor of the enzyme CYP17A1. By specifically targeting the cytochrome P450 enzyme CYP17, it effectively inhibits both 17α-hydroxylase and 17,20-lyase activities, displaying IC50 values of 2.5 nM and 15 nM, respectively. This reagent is crucial for studies investigating androgen synthesis pathways and the development of therapies for hormone-sensitive cancers.
Abiraterone-d4, a deuterium-labeled derivative of Abiraterone, functions as a potent and irreversible inhibitor of the enzyme CYP17A1. By specifically targeting the cytochrome P450 enzyme CYP17, it effectively inhibits both 17α-hydroxylase and 17,20-lyase activities, displaying IC50 values of 2.5 nM and 15 nM, respectively. This reagent is crucial for studies investigating androgen synthesis pathways and the development of therapies for hormone-sensitive cancers.
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