ABT-751 hydrochloride is a potent sulfonamide antimitotic compound that functions primarily as a tubulin binder. By binding to the colchicine site on β-tubulin, it prevents tubulin aggregation, leading to cell cycle arrest in the G2/M phase and subsequent apoptosis. Additionally, ABT-751 hydrochloride induces autophagy through the inhibition of the AKT/mTOR signaling pathway. This compound demonstrates significant antiproliferative effects against a range of cancer cell types, including lung, gastric, colon, and breast cancer.
ABT-751 hydrochloride is a potent sulfonamide antimitotic compound that functions primarily as a tubulin binder. By binding to the colchicine site on β-tubulin, it prevents tubulin aggregation, leading to cell cycle arrest in the G2/M phase and subsequent apoptosis. Additionally, ABT-751 hydrochloride induces autophagy through the inhibition of the AKT/mTOR signaling pathway. This compound demonstrates significant antiproliferative effects against a range of cancer cell types, including lung, gastric, colon, and breast cancer.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
