ABT-751 (E-7010)

Name: ABT-751 (E-7010)
Brand: Adooq Bioscience
SKU: A10024
Rating: 100 (268 reviews)

Catalog No.: A10024

Microtubule Associated inhibitor

ABT-751 (E-7010) Chemical Structure

CAS NO. 141430-65-1

ABT-751 is an antimitotic agent, inhibits microtubule polymerization, binds to β-tubulin on the colchine site; blocks cell cycle at G2M phase and induces apoptosis.

Availability: In stock

Package	Price	Qty
10 mg	$80.00
50 mg	$270.00
100 mg	$450.00
200 mg	$700.00
10mM * 1mL in DMSO	$92.00
Custom Size	Get quote

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Biological Activity

ABT-751 is an antimitotic agent, inhibits microtubule polymerization, binds to β-tubulin on the colchine site; blocks cell cycle at G2M phase and induces apoptosis.

Targets

Microtubules

Solubility *

In vitro (25°C)	DMSO	71 mg/mL (191.16 mM)
	Water	Insoluble
	Ethanol	12 mg/mL (32.3 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.93 mL	134.63 mL	269.25 mL
0.5 mM	5.39 mL	26.93 mL	53.85 mL
1 mM	2.69 mL	13.46 mL	26.93 mL
5 mM	0.54 mL	2.69 mL	5.39 mL

*The above data is based on the productmolecular weight 371.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10024
Actions	Inhibitor
CAS No.	141430-65-1
Formula	C18H17N3O4S
M. Wt	371.4
Purity	>98%
Synonyms	ABT751
SMILES	COC1=CC=C(C=C1)S(=O)(=O)NC2=C(N=CC=C2)NC3=CC=C(C=C3)O
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.