ABT-751 (E-7010)

Catalog No.: A10024

Microtubule Associated inhibitor

ABT-751 (E-7010) Chemical Structure

CAS NO. 141430-65-1

ABT-751 is an antimitotic agent, inhibits microtubule polymerization, binds to β-tubulin on the colchine site; blocks cell cycle at G2M phase and induces apoptosis.

Availability: In stock

Package Price Qty
10 mg
$80.00
50 mg
$270.00
100 mg
$450.00
200 mg
$700.00
10mM * 1mL in DMSO
$92.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

ABT-751 is an antimitotic agent, inhibits microtubule polymerization, binds to β-tubulin on the colchine site; blocks cell cycle at G2M phase and induces apoptosis.
Targets
Microtubules
In vitro (25°C) DMSO 74 mg/mL (199.24 mM)
Water <1 mg/mL (<1 mM)
Ethanol 12 mg/mL (32.3 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.93 mL 134.63 mL 269.25 mL
0.5 mM 5.39 mL 26.93 mL 53.85 mL
1 mM 2.69 mL 13.46 mL 26.93 mL
5 mM 0.54 mL 2.69 mL 5.39 mL

*The above data is based on the productmolecular weight 371.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10024
Actions Inhibitor
M. Wt 371.4
Formula C18H17N3O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 141430-65-1
Synonyms ABT751
SMILES COC1=CC=C(C=C1)S(=O)(=O)NC2=C(N=CC=C2)NC3=CC=C(C=C3)O

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