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AC-178335

Catalog No.: A63887
SRIF Antagonist
AC-178335 is a selective antagonist of somatostatin receptor type 2 (SRIF), exhibiting a Ki value of 172 nM. It effectively inhibits the SRIF-mediated suppression of adenylate cyclase with an IC50 of 5.1 μM in vitro. This compound has demonstrated the capability to induce growth hormone release in anesthetized rat models, making it a valuable tool for investigating the physiological role of somatostatin signaling in endocrine regulation.
AC-178335 212966-15-9 SRIF Antagonist
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Size Price Stock Qty
25mg
$1,275.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAC-178335 is a selective antagonist of somatostatin receptor type 2 (SRIF), exhibiting a Ki value of 172 nM. It effectively inhibits the SRIF-mediated suppression of adenylate cyclase with an IC50 of 5.1 μM in vitro. This compound has demonstrated the capability to induce growth hormone release in anesthetized rat models, making it a valuable tool for investigating the physiological role of somatostatin signaling in endocrine regulation.
Product Information
Catalog NumA63887
FormulaC49H63N13O7
Molecular Weight946.11
CAS Number212966-15-9
SequenceAc-{d-(His-Phe-Ile-Arg-Trp-Phe)}-NH2
Sequence shorteningAc-{d-(HFIRWF)}-NH2
SMILESC([C@@H](NC([C@H](NC([C@H](NC([C@@H](CC1=CC=CC=C1)NC([C@@H](CC2=CN=CN2)NC(C)=O)=O)=O)[C@@H](CC)C)=O)CCCNC(=N)N)=O)C(N[C@H](CC3=CC=CC=C3)C(N)=O)=O)C=4C=5C(NC4)=CC=CC5
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GPCR/G Protein > Somatostatin Receptors