Ac-RYYRIK-NH2 serves as a potent partial agonist of the ORL1 receptor, exhibiting a dissociation constant (Kd) of 1.5 nM in CHO cell models. This compound mimics the action of endogenous ligands, facilitating research into ORL1-related pathways. Additionally, it acts as a specific antagonist for G protein activation, competitively inhibiting [35S]-GTPgS binding stimulated by nociceptin/orphanin FQ in rat brain membranes and sections. Applications include studies of pain modulation, neuropharmacology, and the underlying mechanisms of ORL1 receptor signaling.
Ac-RYYRIK-NH2 serves as a potent partial agonist of the ORL1 receptor, exhibiting a dissociation constant (Kd) of 1.5 nM in CHO cell models. This compound mimics the action of endogenous ligands, facilitating research into ORL1-related pathways. Additionally, it acts as a specific antagonist for G protein activation, competitively inhibiting [35S]-GTPgS binding stimulated by nociceptin/orphanin FQ in rat brain membranes and sections. Applications include studies of pain modulation, neuropharmacology, and the underlying mechanisms of ORL1 receptor signaling.
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