Ac-RYYRWK-NH2 TFA serves as a potent and selective partial agonist for the nociceptin receptor (NOP). It exhibits significant binding affinity, with a Kd of 0.071 nM for rat cortical membranes (ORL1), while demonstrating no affinity for μ-, κ-, or δ-opioid receptors. This compound is valuable for research investigating nociceptin signaling pathways and their implications in pain modulation and various neurological disorders.
Ac-RYYRWK-NH2 TFA serves as a potent and selective partial agonist for the nociceptin receptor (NOP). It exhibits significant binding affinity, with a Kd of 0.071 nM for rat cortical membranes (ORL1), while demonstrating no affinity for μ-, κ-, or δ-opioid receptors. This compound is valuable for research investigating nociceptin signaling pathways and their implications in pain modulation and various neurological disorders.
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