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Biological Activity
ACX-362E is an orally available DNA polymerase IIIC (pol IIIC) inhibitor, acts as an antimicrobial agent to treat Gram-positive infections, with a MIC50 of 2 μg/mL for C. difficile. ACX-362E displays very potent in vitro and in vivo activities against broad spectrum of C. difficile pathogens.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.62 mL | 118.12 mL | 236.24 mL |
| 0.5 mM | 4.72 mL | 23.62 mL | 47.25 mL |
| 1 mM | 2.36 mL | 11.81 mL | 23.62 mL |
| 5 mM | 0.47 mL | 2.36 mL | 4.72 mL |
*The above data is based on the productmolecular weight 423.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18560 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1275582-97-2 |
| Formula | C18H20Cl2N6O2 |
| M. Wt | 423.3 |
| Purity | >98% |
| SMILES | O=C1NC(NCC2=CC=C(Cl)C(Cl)=C2)=NC3=C1N(CCN4CCOCC4)C=N3 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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